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. 2022 Mar 12;211:113047. doi: 10.1016/j.envres.2022.113047

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Fig. 7 — The possible recombination-mediated evolution of Type-III S1-NTD in the SARS-CoV-2 related viruses. (A to C) Phylogenetic tree generated from the RDP using the complete genome sequences of the representative SARS-CoV-2 and SARS-CoV. The recombination events in the spike gene Type-III S1-NTD of SARS-CoV-2-related bat viruses are supported by RDP, BootScan, MaxChi, Chimaera, SiScan, and 3Seq. The RDP-based phylogenetic tree using (A) complete genome with UPGMA phylogenetic analysis; (B) recombinant area of the 1–21767 and 22585-30082 nts with UPGMA phylogenetic analysis; and (C) recombinant region of 21768–22584 nt (S1-NTD) nts with UPGMA phylogenetic analysis. (D) Similarity plot based on the complete genomes nucleotide sequences of the representative SARS-CoV-2 and SARS-CoV. The RmYN02 is used as a reference sequence query. It indicates the possible recombination-mediated evolution of Type-III S1-NTDs in the SARS-COV-2 related viruses from the SARS-CoVs S1-NTD.