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. Author manuscript; available in PMC: 2022 Mar 12.
Published in final edited form as: J Am Chem Soc. 2019 Jan 31;141(6):2678–2683. doi: 10.1021/jacs.8b13079

Figure 4.

Figure 4.

Several changes occur in the B–C loop of P450cam. In the structure, two prolines undergo cis–trans isomerization including (A) Pro89, which also moves to a distance of 3.6 Å from Tyr29, as well as (B) Pro105. (C) Tyr96 also rotates out of the active site where it H-bonds with the camphor carbonyl oxygen. Camphor (yellow); heme (red). 2Fo-Fc maps at 1 σ (blue).