Table 1.
Participant characteristics
| HA | MDD | P Value | |
|---|---|---|---|
| n (men/women) | 11 (6/5) | 14 (4/10) | 0.24 |
| Body weight, kg | 73 ± 19 | 64 ± 15 | 0.19 |
| Height, cm | 169.6 ± 13.6 | 166.7 ± 8.8 | 0.52 |
| Body mass index, kg/m2 | 25.0 ± 3.0 | 22.8 ± 4.0 | 0.16 |
| Total physical activity, min/day | 231 ± 333 | 273 ± 203 | 0.71 |
| Cardiovascular | |||
| SBP, mmHg | 115 ± 11 | 114 ± 9 | 0.73 |
| DBP, mmHg | 74 ± 7 | 74 ± 6 | 0.79 |
| MAP, mmHg | 87 ± 8 | 87 ± 7 | 0.99 |
| HR, beats/min | 76 ± 12 | 72 ± 10 | 0.36 |
| Depression severity | |||
| PROMIS, raw score | 15 ± 6 | 24 ± 6 | 0.0004* |
| PROMIS, T score | 52 ± 7 | 62 ± 6 | 0.0008* |
| PHQ-9, AU | 2 ± 2 | 9 ± 6 | 0.0013* |
| T cells | |||
| %CD3+, lymphocytes | 61 ± 12 | 67 ± 8 | 0.16 |
| %CD4+, CD3+ | 50 ± 7 | 50 ± 11 | 0.87 |
| %CD8+, CD3+ | 37 ± 5 | 34 ± 8 | 0.27 |
| CD4-to-CD8 ratio | 1.38 ± 0.39 | 1.60 ± 0.69 | 0.36 |
Values are represented as means ± SD; n, number of participants. AU, arbitrary units; SBP, systolic blood pressure; DBP, diastolic blood pressure; HA, healthy nondepressed young adults; HR, heart rate; MAP, mean arterial pressure; MDD, major depressive disorder; PHQ-9, patient health questionnaire (symptom severity: 0–4, minimal; 5–9, mild; 10–14, moderate; 15–19, moderately severe; 20–27, severe); PROMIS, patient-reported outcome measurement information system; SBP, systolic blood pressure. All data, except sex ratios (Fisher’s exact test), were analyzed using Student’s unpaired sample t test. *P < 0.05, significantly greater in MDD compared with HA.