Figure 3.

Ubiquitous expression of decorin and downregulation in various malignant tissues. A: from data generated in GTEx tissue expression via the Xena database provided by the University of California in San Diego, decorin is expressed at measurable levels ubiquitously in different tissue types, further expounding its pertinent function in maintaining wild type, and healthy tissue function. Expression is measured via fragments/Kb of transcripts/million mapped reads (FPKM). B: from a cohort of 19,131 patients with cancer aggregate in the TCGA Target GTEx database published by UCSD, normal and tumor tissue RNA-Seq signaling was measured in a variety of tissue types ranging from esophageal to ovarian. These data illustrate a significant downregulation (P values ranging from 1.74 × 10⁻⁸ to 2.63 × 10⁻²⁰⁶) of decorin in tumorigenic tissue. These findings strongly indicate that higher decorin concentrations are beneficial in preventing primary tumor growth and proliferation. Along with its ubiquitous expression in mammalian tissue, decorin is a nondiscriminant antitumorigenic agent.