Table 1.

Male insulin BBB pharmacokinetics following acute exercise

Region	Treatment	Ki, µL/g·min	Ki P Value	r	Vi, µL/g	Vi P Value
Whole brain	Sedentary	0.95 ± 0.18	0.0072	0.88	6.3 ± 1.2
	Exercise	1.81 ± 0.21		0.91	6.5 ± 1.1
Olfactory bulb	Sedentary	3.70 ± 0.42	0.710	0.98	−1.0 ± 2.5	0.0001
	Exercise	4.06 ± 0.63		0.91	10.1 ± 2.8
Hypothalamus	Sedentary	4.28 ± 0.10	0.347	0.92	−0.7 ± 5.4	0.305
	Exercise	2.84 ± 0.95		0.65	9.3 ± 4.3

BBB, blood-brain barrier; K_i, linear transport ± standard error mean; P value, difference between sedentary and exercise within brain region; r, correlation coefficient, V_i, level of reversible vascular binding ± SE.