Table 2.

Female insulin BBB pharmacokinetics following acute exercise

Region	Treatment	Ki, µL/g·min	Ki P Value	r	Vi, µL/g	Vi P Value
Whole brain	Sedentary	1.94 ± 0.23	0.998	0.95	4.8 ± 1.3	0.054
	Exercise	1.94 ± 0.40		0.81	7.3 ± 1.8
Olfactory bulb	Sedentary	3.93 ± 0.88	0.746	0.80	10.7 ± 6.1	0.694
	Exercise	3.55 ± 0.70		0.74	14.6 ± 4.6
Hypothalamus	Sedentary	2.79 ± 0.83	0.057	0.89	2.9 ± 6.3	0.004
	Exercise	1.45 ± 0.23		0.91	1.1 ± 2.2

BBB, blood-brain barrier; K_i, linear transport ± standard error mean; P value, difference between Sedentary and Exercise within brain region; r, correlation coefficient; V_i, level of reversible vascular binding ± SE.