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. 2022 Feb 7;322(3):E307–E318. doi: 10.1152/ajpendo.00234.2021

Figure 4.

Figure 4.

Sacubitril increases insulin content in a GLP-1R-dependent manner. Insulin content at the end of the 8-wk treatment period in VEH-CTL (n = 10), STZ-CTL (n = 10), and STZ-SAC (n = 12) groups of male Glp1r+/+ mice (A) and VEH-CTL (n = 8), STZ-CTL (n = 8), and STZ-SAC (n = 6) groups of male Glp1r−/− mice (B). *P ≤ 0.05 (analyzed using one-way or Brown–Forsythe ANOVA followed by Dunnet’s multiple comparisons test). Data are means ± SE. GLP-1R, glucagon-like peptide-1 receptor; SAC, sacubitril; STZ, streptozotocin; VEH, vehicle.