Table 1.

Fasting plasma glucose and insulin, body weight gain, fat pad mass, and pancreas weight in Glp1r^+/+ mice injected with vehicle (VEH) or streptozotocin (STZ) and fed HFD alone (control, CTL) or HFD supplemented with sacubitril (SAC) for 8 wk

	VEH-CTL	STZ-CTL	STZ-SAC	ANOVA P Value
Fasting plasma glucose, mg/dL	258.7 ± 8.43	345.6 ± 22.01*	298.8 ± 22.1#	0.0007
Fasting plasma insulin, pmol/L	509.4 ± 71.13	349.1 ± 51.06	305.8 ± 35.40	0.0291
Body weight gain, g	14.45 ± 1.25	10.92 ± 0.85*	10.46 ± 0.91	0.0181
Inguinal fat pad mass, g	1.91 ± 0.19	1.59 ± 0.17	1.40 ± 1.17	0.1581
Epididymal fat pad mass, g	0.236 ± 0.027	0.207 ± 0.020	0.175 ± 0.018	0.1598
Pancreas weight, g	0.298 ± 0.015	0.303 ± 0.015	0.319 ± 0.024	0.7173

Data are expressed as means ± SE. One-way ANOVA was performed to determine whether the means were significantly different across the three groups of mice and the overall P value is displayed in the far right column. If ANOVA P < 0.05, Dunnet’s multiple comparisons were performed and are displayed as followed: *P < 0.05 vs. STZ-CTL vs. VEH-CTL; #STZ-SAC vs. STZ-CTL. CTL, control; HFD: high-fat diet; SAC, sacubitril; STZ, streptozotocin; VEH, vehicle.