Figure 2.

α₂-Macroglobulin (A2M) correlated with dilation and predicted myocardial infarction (MI) death. ELL-associated factor 1 (EAF1) and A2M were higher in nonsurvivors both at baseline and MI day 3 (A). Data were analyzed using linear mixed-effects model with Tukey’s post hoc test. Circles represent males and triangles represent females. Plasma A2M tracked with D3 diastolic and systolic volume (B). Data were analyzed by Pearson’s correlation analysis. Circles represent males and triangles represent females. A2M increased in patients with MI (C). Data were analyzed by unequal variance t test. Gene ontology pathway analysis of proteins that correlate with A2M in humans (P < 0.05) revealed enrichment of the cytokine-mediated signaling pathway, cellular response to cytokine stimulus and negative regulation of wound healing, all biological processes involved in wound healing (D). *P < 0.05. D3, day 3. n represents number of animals (A) or subjects (C) in each group.