Figure 3.

α₂-Macroglobulin (A2M) showed a biphasic effect on myocardial infarction (MI)-induced dilation. In a second cohort of mice high levels of plasma A2M at MI day (D) 3 tracked with lower diastolic volume (A), whereas high levels of plasma A2M at MI D7 tracked with higher diastolic volume (B). Similar to D7 plasma, A2M in left ventricle infarct (LVI) tissue tracked with diastolic volume (C). Interestingly, A2M in D3 plasma predicted A2M in tissue at D7 (D), whereas A2M in D7 plasma did not reflect tissue concentrations (E). All data were analyzed by Pearson’s correlation analysis. Circles represent males and triangles represent females.