Table 3.
Echocardiography at baseline (day 0) and MI days 3 and 7, and necropsy at MI day 7 in the second cohort of mice
| Day 0 | MI Day 3 | MI Day 7 | |
|---|---|---|---|
| Heart rate, beats/min | 482 ± 12 | 506 ± 9 | 520 ± 10 |
| Diastolic volume, µL | 54 ± 2 | 65 ± 2* | 92 ± 6*# |
| Systolic volume, µL | 20 ± 1 | 48 ± 2* | 76 ± 6*# |
| Stroke volume, µL | 34 ± 1 | 17 ± 1* | 16 ± 1* |
| Ejection fraction, % | 63 ± 2 | 26 ± 2* | 19 ± 2*# |
| Infarct size, % | NA | NA | 51 ± 2 |
| LV mass, mg | NA | NA | 91 ± 3 |
| RV mass, mg | NA | NA | 19 ± 0 |
| Lung mass wet, mg | NA | NA | 239 ± 17 |
Values are means ± SE. Data were analyzed using linear mixed effects model analysis and Tukey’s post hoc test. *P < 0.05 compared with day 0; #P < 0.05 compared with day 3. MI, myocardial infarction; NA, not applicable; LV, left ventricular; RV, right ventricular.