Table 1.
Subject characteristics
| Protocol 1 | Protocol 2 | P Values | Merged Data | |
|---|---|---|---|---|
| Subject, n (M/F) | 9 (6/3) | 12 (8/4) | – | 21 (14/7) |
| Age, yrs | 73 ± 8 | 74 ± 7 | 0.98 | 73 ± 7 |
| Height, cm | 173 ± 11 | 170 ± 9 | 0.42 | 171 ± 9 |
| Mass, kg | 72 ± 18 | 78 ± 21 | 0.73 | 76 ± 20 |
| BMI, kg/m2 | 24 ± 4 | 27 ± 5 | 0.33 | 26 ± 5 |
| MAP, mmHg | 94 ± 10 | 91 ± 5 | 0.1 | 92 ± 4 |
| BH4 dose, mg/kg | 10.1 ± 0.4 | 9.9 ± 0.4 | 0.38 | 10 ± 0.04 |
| Total cholesterol, mg/dL | 187 ± 24 | 158 ± 30 | 0.03 | 170 ± 31 |
| LDL, mg/dL | 100 ± 14 | 92 ± 23 | 0.33 | 95 ± 20 |
| HDL, mg/dL | 61 ± 16 | 50 ± 15 | 0.12 | 55 ± 16 |
| CHOL/HDL | 3 ± 1 | 3 ± 1 | 0.86 | 3 ± 1 |
| Triglycerides, mg/dL | 106 ± 47 | 94 ± 47 | 0.58 | 99 ± 46 |
| Plasma glucose, mg/dL | 85 ± 14 | 101 ± 35 | 0.23 | 94 ± 28 |
| Hemoglobin, g/dL | 14.6 ± 1.3 | 14.1 ± 1.4 | 0.41 | 14.3 ± 1.3 |
| HCT, % | 43.5 ± 1.3 | 41.9 ± 4.8 | 0.38 | 42.6 ± 4.2 |
| eGFR, mL/min/1.73m2 | 71 ± 13 | 72 ± 13 | 0.87 | 71 ± 12 |
BH4, tetrahydrobiopterin; BMI, body mass index; eGFR, estimated glomerular filtration rate; HCT, hematocrit; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MAP, mean arterial pressure (upright seated). P values, statistical comparison between Protocol 1 and Protocol 2. Differences between protocols were tested with unpaired Student’s t tests. Data presented as means ± SD.