Figure 3.

IL10RA expression in human profibrotic macrophages. A, top: scRNA-Seq analysis of macrophages identified by SingleR (4) from IPF lungs (17) (n = 17 separate individuals); bottom: feature plot for IL10RA. B: dot plot of expression of M2c markers for clusters identified in A. C: expression of lineage specific markers (alveolar macrophages, FABP4, and moMacs, MAFB) for clusters identified in A. IPF, idiopathic pulmonary fibrosis; moMacs, monocyte-derived macrophages; scRNA-Seq, single-cell RNA-Seq.