Figure 2.

Blood pressure and vascular resistance. Male C57BL/6J mice were exposed to 16 or 60 wk of either air or electronic cigarette (e-cig) vape generated from e-cig liquid containing nicotine (NIC) 0 mg/mL (ECV-0), 6 mg/mL (ECV-6), or 24 mg/mL (ECV-24). A: systolic blood pressure (SBP). B: diastolic blood pressure (DBP). C: mean arterial blood pressure (MABP). D: systemic vascular resistance (SVR). ECV exposure resulted in a NIC-and an exposure time-dependent vascular endothelial dysfunction with elevated MABP and SVR. Data are presented as means ± SE of 6 mice. Each point represents the average of at least 10 measurements per animal. Analysis was done using two-way ANOVA followed by Bonferroni multiple-comparisons test. The differences were considered statistically significant at P ≤ 0.05. *Significant from air-exposed controls at P < 0.05; #significant from ECV-0 at P < 0.05; @significant from ECV-6 at P < 0.05; $significant from the same exposure at 16 wk at P < 0.05.