Table 1.
Endothelium-dependent and -independent vascular reactivity data
| RC50, nM |
Rmax, % |
|||
|---|---|---|---|---|
| 16 wk | 60 wk | 16 wk | 60 wk | |
| Acetylcholine | ||||
| Air | 42 ± 5 | 154 ± 6 | 95 ± 4 | 85 ± 4 |
| ECV-0 | 156 ± 13* | 745 ± 21*$ | 82 ± 3* | 65 ± 4*$ |
| ECV-6 | 270 ± 18*# | 1,390 ± 41*#$ | 79 ± 5* | 60 ± 6*$ |
| ECV-24 | 650 ± 25*#@ | – | 64 ± 4*#@ | 44 ± 4*#@$ |
| Sodium nitroprusside | ||||
| Air | 8.0 ± 0.7 | 8.6 ± 2 | 96 ± 5 | 94 ± 7 |
| ECV-0 | 19 ± 2* | 22 ± 3* | 85 ± 6 | 80 ± 4*$ |
| ECV-6 | 34 ± 4*# | 54 ± 4*#$ | 80 ± 2* | 75 ± 4* |
| ECV-24 | 54 ± 4*#@ | 92 ± 5*#@$ | 68 ± 3*#@ | 58 ± 3*#@$ |
Values are means ± SE. ECV-0, electronic cigarette (e-cig) vape generated from e-cig liquid containing nicotine 0 mg/mL; ECV-6, electronic cigarette (e-cig) vape generated from e-cig liquid containing nicotine 6 mg/mL; ECV-24, electronic cigarette (e-cig) vape generated from e-cig liquid containing nicotine 24 mg/mL; RC50, concentration of acetylcholine/sodium nitroprusside that produces 50% relaxation of phenylephrine-preconstricted aortic rings; Rmax, maximum acetylcholine/sodium nitroprusside-induced relaxation. *P < 0.05, significant from air-exposed controls; #P < 0.05, significant from ECV-0; @P < 0.05, significant from ECV-6; $P < 0.05, significant from the same exposure at 16 wk.