Figure 5.

Heart rate and stroke volume from 12 to 18 wk of age and heart weight at 19 wk of age in high-fat diet (HFD)-fed hypertensive rats treated with vehicle (n = 14 or 15), empagliflozin (EMPA) (n = 8), praliciguat (PRL) (n = 10) or EMPA + PRL (n = 10). Bars show means ± SE. Differences vs. basal period (week 12) were assessed with the use of one-way ANOVA for repeated measures with Holm–Sidak’s multiple comparison test. Differences between groups were assessed with the use of two-way ANOVA with Tukey’s multiple comparisons analysis. ^eP < 0.05 vs. week 12.