Figure 7.

Effects of pulmonary macrophage transplantation (PMT) on genome-wide gene expression of the alveolar macrophage (AM) population in Csf2ra^–/– mice. A: unsupervised hierarchical clustering dendrogram for AMs obtained from age-matched mice (3 mice/group) including untreated Csf2ra^–/– mice (knockout, KO), PMT-treated Csf2ra^–/– mice (KO + PMT), and untreated Csf2ra^+/+ mice (wild type, WT). B: heat maps showing differentially expressed granulocyte/macrophage-colony stimulating factor (GM-CSF)-regulated genes peroxisome proliferator-activated receptor gamma (PPARγ)-regulated genes, and genes in KEGG pathways related to cell cycle control, apoptosis, peroxisome function, glycophospholipid metabolism, and immune host defense. Genes with increased or decreased transcript levels are shown by red and blue colors, respectively, as indicated on the color scale.