Table 1.
Hematological indices in PMT-treated and age-matched, untreated Csf2ra–/–mice*
| Parameter | Normal Range | PMT-Treated (n = 12) |
No PMT (n = 11) |
|---|---|---|---|
| Evaluation 2 mo after PMT | |||
| Hemoglobin, g/dL | 11.0–15.1 | 11.7 [10.9–12.2] | 10.5 [9.7–11.8] |
| Hematocrit, % | 35.1–45.4 | 41.2 [38.9–41.7] | 38.0 [34.0–39.6] |
| WBC, ×103/µL | 1.8–10.7 | 4.1 [3.3–5.09] | 3.8 [2.5–4.8] |
| Neutrophils, ×103/µL | 0.1–2.4 | 1.3 [1.2–1.50] | 0.5 [0.4–0.6] |
| Lymphocytes, ×103/µL | 0.9–9.3 | 2.4 [1.8–2.66] | 2.7 [1.9–3.7] |
| Monocytes, ×103/µL | 0.0–0.4 | 0.2 [0.2–0.38] | 0.47 [0.4–0.60] |
| Eosinophils, ×103/µL | 0.0–0.2 | 0.0 [0.0–0.02] | 0.02 [0.0–0.08] |
| Basophils, ×103/µL | 0.0–0.2 | 0.00 [0.0–0.00] | 0.01 [0.0–0.02] |
| Platelets, ×103/µL | 592–2972 | 904 [749–959] | 829 [624–849] |
| Parameter | Normal Range | PMT (n = 18) |
No PMT (n = 12) |
|---|---|---|---|
| Evaluation 6 mo after PMT | |||
| Hemoglobin, g/dL | 11.0–15.1 | 12.1 [11.6–12.50] | 12.4 [12.2–12.8] |
| Hematocrit, % | 35.1–45.4 | 38.2 [35.6–39.6] | 40.3 [39.6–41.8] |
| White blood cell count, ×103/µL | 1.8–10.7 | 3.1 [2.9–4.01] | 4.0 [3.8–4.4] |
| Neutrophils, ×103/µL | 0.1–2.4 | 0.3 [0.2–0.65] | 0.6 [0.5–0.82] |
| Lymphocytes, ×103/µL | 0.9–9.3 | 2.3 [2.0–2.96] | 2.79 [2.4–3.01] |
| Monocytes, ×103/µL | 0.0–0.4 | 0.3 [0.3–0.47] | 0.48 [0.3–0.62] |
| Eosinophils, ×103/µL | 0.0–0.2 | 0.03 [0.0–0.47] | 0.06 [0.0–0.09] |
| Basophils, ×103/µL | 0.0–0.2 | 0.01 [0.0–0.02] | 0.01 [0.0–0.04] |
| Platelets, ×103/µL | 592–2,972 | 573 [492–709] | 680 [580–798] |
*
Data are median and interquartile range.
PMT, pulmonary macrophage transplantation (direct intrapulmonary instillation of congenic, wild-type, bone-marrow-derived macrophages).