Figure 2.

Gut microbiome composition at genus levels exhibits different patterns for acute patients with schizophrenia with acutely exacerbated symptoms (SCZ-AE) and those treated with amisulpride for 4 weeks (SCZ-T). Principal coordinate analysis (PCoA) based on the distance function of Bray–Curtis (a). Cladogram using LEfSe method showed the largest differences in taxa between SCZ-AE and SCZ-T (b). The color-coded bar chart shows the most prevalent genera present before and after in amisulpride treatment (c). Differences in the fecal microbiota at the genus level (d). Significant butanoate metabolism pathway downregulation was shown for the fecal microbiome in SCZ-T (e). Statistical analysis was performed with the Kruskal–Wallis test. ^∗P < 0.05 compared with SCZ-AE.