Table 1:
Clinicopathologic characteristics of all resected colorectal liver metastasis (CRLM) patients, stratified by age at primary colorectal tumor diagnosis.
| All patients | Early-Onset | Screening Age | p-value | ||
|---|---|---|---|---|---|
|
| |||||
| Number of patients | 1822 | 570 (31.3) | 1252 (68.7) | ||
|
| |||||
| Age at Diagnosis, years | Median (range) | 57 (18, 90) | 44 (18, 49) | 62 (50, 90) | |
|
| |||||
| Gender | Male | 1008 (55.3) | 306 (53.7) | 702 (56.1) | 0.400 |
| Female | 814 (44.7) | 264 (46.3) | 550 (43.9) | ||
|
| |||||
| Primary Tumor Location | Right Colon | 517 (28.4) | 118 (20.7) | 399 (31.9) | <0.001 |
| Left Colon | 700 (38.4) | 228 (40.0) | 472 (37.7) | ||
| Rectum | 597 (32.8) | 223 (39.1) | 374 (29.9) | ||
| Multifocal | 6 (0.3) | 1 (0.2) | 5 (0.4) | ||
| Colon, NOS | 2 (0.1) | 0 (0.0) | 2 (0.2) | ||
|
| |||||
| Primary Pathologic Nodal Status | N0 | 636 (34.9) | 161 (28.2) | 475 (37.9) | <0.001 |
| N+ | 1170 (64.2) | 405 (71.1) | 765 (61.1) | ||
| Unknown | 16 (0.9) | 4 (0.7) | 12 (1.0) | ||
|
| |||||
| Disease Free Interval | < 12 months | 1413 (77.6) | 474 (83.2) | 939 (75.0) | <0.001 |
| ≥ 12 months | 331 (18.2) | 72 (12.6) | 259 (20.7) | ||
| Unknown | 78 (4.3) | 24 (4.2) | 54 (4.3) | ||
|
| |||||
| Preoperative CEA | < 200 ng/mL | 1535 (84.2) | 476 (83.5) | 1059 (84.6) | 0.058 |
| ≥ 200 ng/mL | 101 (5.5) | 41 (7.2) | 60 (4.8) | ||
| Unknown | 186 (10.2) | 53 (9.3) | 133 (10.6) | ||
|
| |||||
| Largest CRLM Size | < 5 cm | 1398 (76.6) | 443 (77.5) | 955 (76.1) | 0.300 |
| ≥ 5 cm | 357 (19.8) | 103 (18.2) | 254 (20.4) | ||
| Unknown | 67 (3.7) | 24 (4.2) | 43 (3.4) | ||
|
| |||||
| Number of CRLM | Solitary | 606 (33.2) | 156 (27.2) | 450 (35.9) | <0.001 |
| Multifocal | 1144 (62.8) | 390 (68.6) | 754 (60.2) | ||
| Unknown | 72 (4.0) | 24 (4.2) | 48 (3.8) | ||
|
| |||||
| Clinical Risk Score (CRS) | Low Risk (0–2) | 811 (44.5) | 205 (36.0) | 606 (48.4) | <0.001 |
| High Risk (3–5) | 763 (41.9) | 290 (50.9) | 473 (37.8) | ||
| Unknown | 248 (13.6) | 75 (13.2) | 173 (13.8) | ||
|
| |||||
| Preoperative Chemotherapy | Yes | 1243 (68.2) | 425 (74.6) | 818 (65.3) | <0.001 |
| No | 579 (31.8) | 145 (25.4) | 434 (34.7) | ||
|
| |||||
| Hepatic Artery Infusion Chemotherapy | None | 995 (54.6) | 246 (43.2) | 749 (59.8) | <0.001 |
| Preoperative | 61 (3.3) | 31 (5.4) | 30 (2.4) | ||
| Adjuvant | 678 (37.2) | 258 (45.3) | 420 (33.5) | ||
| Salvage | 88 (4.8) | 35 (6.1) | 53 (4.2) | ||
|
| |||||
| Time from Primary Diagnosis to Resection, weeks | Median (range) | 40 (23, 82) | 35 (20, 69) | 43 (24, 90) | <0.001 |
|
| |||||
| Extent of Hepatectomy | Minor | 1139 (62.5) | 356 (62.5) | 783 (62.5) | >0.900 |
| Major | 683 (37.5) | 214 (37.5) | 469 (37.5) | ||
|
| |||||
| Ablation at Hepatectomy | Yes | 337 (18.5) | 107 (18.8) | 230 (18.4) | 0.900 |
| No | 1485 (81.5) | 463 (81.2) | 1022 (81.6) | ||