Table 2:
Clinicopathologic characteristics of sequenced resected colorectal liver metastasis (CRLM) patients, stratified by age at primary colorectal tumor diagnosis.
| All patients | Early-Onset | Screening Age | p-value | ||
|---|---|---|---|---|---|
|
| |||||
| Number of patients | 333 | 127 (38.1) | 206 (61.9) | ||
|
| |||||
| Age at Diagnosis, years | Median (range) | 54 (23, 84) | 45 (23, 49) | 60 (50, 84) | |
|
| |||||
| Gender | Male | 176 (52.9) | 65 (51.2) | 111 (53.9) | 0.700 |
| Female | 157 (47.1) | 62 (48.8) | 95 (46.1) | ||
|
| |||||
| Primary Tumor Location | Right Colon | 80 (24.0) | 28 (22.0) | 52 (25.2) | 0.700 |
| Left Colon | 142 (42.6) | 56 (44.1) | 86 (41.7) | ||
| Rectum | 104 (31.2) | 42 (33.1) | 62 (30.1) | ||
| Multifocal | 6 (1.8) | 1 (0.8) | 5 (2.4) | ||
| Colon, NOS | 1 (0.3) | 0 (0) | 1 (0.5) | ||
|
| |||||
| Primary Pathologic Nodal Status | N0 | 100 (30.0) | 27 (21.3) | 73 (35.4) | 0.008 |
| N+ | 232 (69.7) | 100 (78.7) | 132 (64.1) | ||
| Unknown | 1 (0.3) | 0 (0) | 1 (0.5) | ||
|
| |||||
| Disease Free Interval | < 12 months | 266 (79.9) | 106 (83.5) | 160 (77.7) | 0.300 |
| ≥ 12 months | 67 (20.1) | 21 (16.5) | 46 (22.3) | ||
|
| |||||
| Preoperative CEA | < 200 ng/mL | 290 (87.1) | 109 (85.8) | 183 (88.8) | 0.200 |
| ≥ 200 ng/mL | 28 (8.4) | 14 (11.0) | 14 (6.8) | ||
| Unknown | 15 (4.5) | 6 (4.2) | 9 (4.4) | ||
|
| |||||
| Largest CRLM Size | < 5 cm | 269 (80.8) | 104 (81.9) | 165 (80.1) | 0.800 |
| ≥ 5 cm | 64 (19.2) | 23 (18.1) | 41 (19.9) | ||
|
| |||||
| Number of CRLM | Solitary | 85 (25.5) | 30 (23.6) | 55 (26.7) | >0.900 |
| Multifocal | 248 (74.5) | 97 (76.4) | 151 (73.3) | ||
|
| |||||
| Clinical Risk Score (CRS) | Low Risk (0–2) | 146 (43.8) | 43 (33.9) | 103 (50.0) | 0.005 |
| High Risk (3–5) | 171 (51.4) | 78 (61.4) | 93 (45.1) | ||
| Unknown | 16 (4.8) | 6 (4.7) | 10 (4.9) | ||
|
| |||||
| Preoperative Chemotherapy | Yes | 216 (64.9) | 85 (66.9) | 131 (63.6) | 0.600 |
| No | 117 (35.1) | 42 (33.1) | 75 (36.4) | ||
|
| |||||
| Hepatic Artery Infusion Chemotherapy | None | 76 (22.8) | 16 (12.6) | 60 (29.1) | <0.001 |
| Preoperative | 0 (0) | 0 (0) | 0 (0) | ||
| Adjuvant | 220 (66.1) | 100 (78.7) | 120 (58.3) | ||
| Salvage | 37 (11.1) | 11 (8.7) | 26 (12.6) | ||
|
| |||||
| Time from Primary Diagnosis to Resection, weeks | Median (range) | 32 (17, 69) | 26 (16, 57) | 35 (18, 75) | 0.024 |
|
| |||||
| Extent of Hepatectomy | Minor | 237 (71.2) | 88 (69.3) | 149 (72.3) | 0.600 |
| Major | 96 (28.8) | 39 (30.7) | 57 (27.7) | ||
|
| |||||
| Ablation at Hepatectomy | Yes | 75 (22.5) | 28 (22.0) | 47 (22.8) | >0.900 |
| No | 258 (77.5) | 99 (78.0) | 159 (77.2) | ||