Table 6.
Standardized Mortality Ratio for Medications Associated with Improvement in PTSD,* among Patients with a Baseline PCL Score of 38 or Higher as well as a PTSD Diagnosis within 30 Days and without Any Concurrent Evidence-Based Treatment
| TreeScan Node | OBS | EXP | O:E | P |
|---|---|---|---|---|
| Antivirals | ||||
| Hepatitis C Virus NS3/4A Protease Inhibitor | 16 | 6 | 2.85 | 0.004 |
| 1Glecaprevir | 14 | 4 | 3.52 | 0.001 |
| Hepatitis C Virus NS5A Protein Inhibitor | 32 | 15 | 2.21 | 0.001 |
| 1Pibrentasvir | 14 | 4 | 3.52 | 0.001 |
|
| ||||
| Antinsychotics | ||||
| Serotonin 2A (5-HT2A) Receptor Antagonist | 2903 | 2656 | 1.10 | 0.001 |
| Serotonin 2C (5-HT2C) Receptor Antagonist | 2634 | 2417 | 1.10 | 0.001 |
|
| ||||
| Addiction Treatments | ||||
| Opioid (Mu/Kappa/Delta) Receptor Antagonist | 256 | 205 | 1.25 | 0.02 |
|
| ||||
| Mood Disorder Treatments | ||||
| Serotonin Transporter Inhibitor | 2841 | 2574 | 1.12 | 0.001 |
| Citalopram | 785 | 632 | 1.25 | 0.001 |
| Trazodone | 992 | 893 | 1.12 | 0.03 |
|
| ||||
| Cognitive Stimulants | ||||
| Nicotine | 610 | 522 | 1.17 | 0.005 |
OBS = Observed Cases; EXP = Expected Cases; O:E = Observed Cases over Expected Cases
Evidence-Based Treatment for PTSD included prolonged exposure, cognitive processing therapy, fluoxetine, sertraline, paroxetine, and venlafaxine.
*
Improved by 15 or more points (compared to 7 points or less or PCL worsening) on the PTSD Checklist.
1
Glecaprevir/Pibrentasvir = Mavyret (fixed-dose tablet of Glecaprevir 100mg and Pibrentasvir 40mg)