Table 1:
PCA patient data split by medial temporal atrophy score
| Characteristic | All N=55 | MTA=0 N = 8 | MTA=1 N = 20 | MTA=2 N = 22 | MTA=3 or 4 N = 5 | p-value |
|---|---|---|---|---|---|---|
| Gender | 0.5 | |||||
| F | 35 (64%) | 6 (75%) | 10 (50%) | 15 (68%) | 4 (80%) | |
| M | 20 (36%) | 2 (25%) | 10 (50%) | 7 (32%) | 1 (20%) | |
| Education, years | 15.6 (2.7) | 15.6 (2.9) | 15.8 (2.7) | 15.1 (2.7) | 16.5 (3.4) | 0.8 |
| APOE e4 positive | 0.2 | |||||
| 0 | 22 (44%) | 6 (75%) | 9 (47%) | 6 (32%) | 1 (25%) | |
| 1 | 28 (56%) | 2 (25%) | 10 (53%) | 13 (68%) | 3 (75%) | |
| Handedness | >0.9 | |||||
| L | 5 (9%) | 1 (12%) | 2 (10%) | 2 (9.1%) | 0 (0%) | |
| L/R | 1 (2%) | 0 (0%) | 0 (0%) | 1 (4.5%) | 0 (0%) | |
| R | 49 (89%) | 7 (88%) | 18 (90%) | 19 (86%) | 5 (100%) | |
| Global PiB SUVR | 2.4 (0.3) | 2.4 (0.3) | 2.3 (0.3) | 2.5 (0.4) | 2.4 (0.4) | 0.2 |
| Age at onset, years | 59.4 (7.0) | 53.6 (2.6) | 58.7 (6.8) | 60.8 (7.2) | 65.2 (5.5) | 0.001a,d |
| Age at scan, years | 64.1 (6.8) | 58.2 (3.2) | 63.2 (6.5) | 65.9 (6.6) | 69.7 (6.3) | <0.001a,d |
| Onset to scan, years | 4.2 (2.5) | 4.1 (1.4) | 3.9 (2.6) | 4.6 (2.9) | 4.1 (1.5) | 0.7 |
| MoCA | 16.7 (6.1) | 17.9 (4.7) | 19.4 (4.5) | 12.9 (6.3) | 20.5 (5.4) | 0.035b,c |
| CDR-SB | 4.2 (3.9) | 2.4 (1.0) | 3.1 (2.7) | 5.8 (5.3) | 4.8 (2.4) | 0.013 |
| MDS-UPDRS III | 4.8 (7.7) | 2.0 (3.2) | 4.0 (8.5) | 7.0 (8.2) | 2.2 (4.5) | 0.3 |
| WAB praxis | 55.8 (5.3) | 56.6 (4.3) | 56.5 (5.7) | 54.9 (4.3) | 55.2 (9.1) | 0.3 |
| AVLT-DR | 2.8 (3.3) | 5.3 (2.4) | 3.5 (4.3) | 1.6 (2.0) | 2.0 (3.4) | 0.008a |
| BNT | 11.5 (3.0) | 12.2 (1.9) | 11.9 (3.1) | 10.6 (3.2) | 12.0 (4.2) | 0.3 |
| Rey O | 4.0 (5.1) | 2.6 (2.2) | 4.8 (5.1) | 4.2 (6.5) | 2.0 (2.0) | 0.5 |
| VOSP cubes | 2.1 (2.4) | 2.3 (2.6) | 1.9 (2.1) | 2.2 (2.8) | 2.0 (2.6) | 0.7 |
| VOSP letters | 10.1 (6.6) | 10.2 (7.1) | 11.6 (5.5) | 9.2 (7.1) | 6.3 (10.1) | 0.5 |
| Auditory attention span * | 5.8 (1.5) | 6.2 (1.0) | 5.8 (1.4) | 5.6 (1.8) | 7.0 (0.0) | 0.7 |
Data shown as mean (standard deviation) or N(%). Categorical variables were compared with Fisher’s exact test; continuous variables were compared using Spearman Correlations (education, age and onset to scan) or linear regression corrected for age at scan (for all clinical tests). Pairwise comparisons were performed using a Tukey’s Honest Significant Difference test.
Pairwise differences between MTA 0 and MTA 2
Pairwise differences between MTA 1 and MTA 2
Pairwise differences between MTA 2 and MTA 3 or 4
Pairwise differences between MTA 0 and MTA 3 or 4
Auditory attention span was tested using the WMS digit span forward longest span APOE = apolipoprotein E; AVLT-DR = Auditory Verbal Learning Test Delayed Recall; BNT = Boston Naming Test; CDR-SB = Clinical Dementia Rating scale sum of boxes; MDS-UPDRS III = Movement Disorders Society Sponsored revision of the Unified Parkinson’s Disease Rating Scale; MoCA = Montreal Cognitive Assessment Battery; PiB = Pittsburgh Compound B; Rey-O = Rey Osterrieth complex figure copy; SUVR = standard uptake value ratio; VOSP = Visual Object and Space Perception battery; WAB = Western Aphasia Battery; WMS = Wechsler Memory Scale