Table 2:
PCA patient data split by presence or absence of a CIS
| Characteristic | Absent, N = 33 | Present, N = 22 | p-value |
|---|---|---|---|
| Gender | 0.2 | ||
| F | 24 (73%) | 11 (50%) | |
| M | 9 (27%) | 11 (50%) | |
| Education, years | 15.7 (2.6) | 15.3 (2.9) | 0.6 |
| APOE e4 positive | >0.9 | ||
| 0 | 13 (45%) | 9 (43%) | |
| 1 | 16 (55%) | 12 (57%) | |
| Handedness | 0.3 | ||
| L | 4 (12%) | 1 (4.5%) | |
| L/R | 0 (0%) | 1 (4.5%) | |
| R | 29 (88%) | 20 (91%) | |
| Global PiB SUVR | 2.4 (0.3) | 2.3 (0.4) | 0.3 |
| Age at onset, years | 60.3 (7.3) | 58.0 (6.4) | 0.2 |
| Age at scan, years | 65.1 (6.9) | 62.6 (6.4) | 0.2 |
| Onset to scan, years | 4.3 (2.6) | 4.2 (2.4) | 0.9 |
| MoCA | 17.2 (6.2) | 16.0 (6.0) | 0.5 |
| CDR-SB | 4.0 (3.8) | 4.5 (4.2) | 0.6 |
| MDS-UPDRS III | 5.1 (8.8) | 4.2 (5.8) | 0.7 |
| WAB praxis | 55.9 (5.9) | 55.7 (4.4) | 0.9 |
| AVLT-DR | 3.0 (3.7) | 2.6 (2.7) | 0.6 |
| BNT | 11.2 (3.4) | 11.9 (2.3) | 0.4 |
| Rey O | 4.8 (6.0) | 2.7 (3.3) | 0.1 |
| VOSP cubes | 2.2 (2.4) | 1.9 (2.4) | 0.8 |
| VOSP letters | 10.7 (6.8) | 9.2 (6.4) | 0.5 |
| Auditory attention span * | 6.0 (1.5) | 5.5 (1.3) | 0.4 |
Data shown as mean (standard deviation). P values calculated using two sample t-tests or Chi-squared tests.
Auditory attention span was tested using the WMS digit span forward longest span. APOE = apolipoprotein E; AVLT-DR = Auditory Verbal Learning Test Delayed Recall; BNT = Boston Naming Test; CDR-SB = Clinical Dementia Rating scale sum of boxes; MDS-UPDRS III = Movement Disorders Society Sponsored revision of the Unified Parkinson’s Disease Rating Scale; MoCA = Montreal Cognitive Assessment Battery; PiB = Pittsburgh Compound B; Rey-O = Rey Osterrieth complex figure copy; SUVR = standard uptake value ratio; VOSP = Visual Object and Space Perception battery; WAB = Western Aphasia Battery; WMS = Wechsler Memory Scale