TABLE 1.
Groups’ demographic data and effect of treatment on outcomes variables
| Group 1 (Treatment) | Group 2 (Control) | |
|---|---|---|
| Sex | 5 M 5F | 5 M 3F |
| Age | 67±5.84 | 67.8±4.41 |
| Education | 11.4±3.1 | 11.6±3.2 |
| AChEIs use | 100% | 100% |
| Family history of dementia | None | None |
| Test |
Baseline mean (SD) |
6 months mean (SD) |
Difference |
Baseline mean (SD) |
6 months mean (SD) |
Difference | Diff‐in‐diff | P | SE | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cognitive deterioration | MMSE (0–30) | 21.20 (1.03) | 22.90(1.20) | 1.70 (+8%) | 22.13 (0.83) | 22.13(0.83) | 0.00 (+0%) | 1.70 | .0008 | 0.4125 |
| CDT (0–9) | 5.40 (1.84) | 6.20 (1.69) | 0.80 (+15%) | 4.75 (1.28) | 4.25 (1.04) | 0.50 (–11%) | 1.30 | .0135 | 0.4684 | |
| Memory |
RAVLT IR (0–75) |
25.20 (5.32) | 26.90 (4.68) | 1.70 (+7%) | 24.75 (2.12) | 22.25 (2.25) | 2.50 (–10%) | 4.20 | .0014 | 1.0875 |
|
RAVLT DR (0–15) |
0.30 (0.67) | 1.20 (1.23) | 0.90 (+300%) | 0.63 (0.92) | 0.13 (0.35) | 0.50 (–80%) | 1.40 | .0046 | 0.4259 | |
| RCF IR (0–36) | 2.40 (2.80) | 4.60 (3.66) | 2.20 (+92%) | 1.50 (2.33) | 0.75 (2.12) | 0.75 (–50%) | 2.95 | .0016 | 0.7785 | |
| Visuospatial abilities | RCF C (0–36) | 23.30 (6.45) | 26.50 (5.15) | 3.20 (+14%) | 24.63 (4.50) | 24.50(4.72) | 0.13 (–1%) | 3.33 | .0603 | 1.6452 |
| Attention | MA (0–60) | 32.00 (6.32) | 32.90 (5.95) | 0.90 (+3%) | 38.25 (7.69) | 35.00(5.95) | 3.25 (–8%) | 4.15 | .0028 | 1.1763 |
| Language and speech | AAT (0– 120) | 100.60 (5.46) | 104.40 (3.92) | 3.80 (+4%) | 103.38 (10.39) | 103.38(10.39) | 0.00 (+0%) | 3.80 | .0142 | 1.3809 |
| Executive functions | FAB (0–18) | 11.80 (1.93) | 15.10 (0.99) | 3.30 (+28%) | 10.88 (2.23) | 9.25 (1.83) | 1.63 (–15%) | 4.93 | <.0000 | 0.5806 |
| STEP (0–40) | 21.20 (5.59) | 24.90 (4.43) | 3.70 (+17%) | 24.00 (4.31) | 21.75 (4.83) | 2.25 (–9%) | 5.95 | <.0000 | 0.9605 | |
| SVF (0–∞ ) | 32.50 (5.06) | 35.80 (4.18) | 3.30 (+10%) | 31.38 (5.10) | 29.50 (3.93) | 1.88 (–6%) | 5.18 | <.0000 | 0.9107 | |
| PVF (0 ‐ ∞) | 24.90 (5.78) | 30.50 (6.70) | 5.60 (+22%) | 27.75 (5.52) | 23.63 (4.90) | 4.13 (–15%) | 9.73 | <.0000 | 1.4194 | |
| Behavioral disorders | NPI (0–144) | 10.70 (5.58) | 5.80 (3.94) | 4.90 (–46%) | 12.00 (7.09) | 12.50 (6.65) | 0.50 (+4%) | –5.40 | .0001 | 1.0797 |
| AES (0–72) | 40.70 (10.72) | 33.60 (8.58) | 7.10 (–17%) | 33.63 (16.49) | 36.13 (15.68) | 2.50 (+7%) | –9.60 | <.0000 | 1.7221 |
Abbreviations: AAT, Aachener Aphasie Test 15 ; AChEI, acetylcholinesterase inhibitor; AES, Apathy Evaluation Scale 17 ; CDT, Clock Drawing Test 11 ; FAB, Frontal Assessment Battery 14 ; MA, Attentive Matrices 13 ; MMSE, Mini Mental State Examination 10 ; NPI, Neuropsychiatric Inventory 18 ; PVF, Phonological Verbal Fluency Test 12 ; RAVLT DR, Rey Auditory Verbal Learning TestDelayed Recall; RAVLT IR, Rey Auditory Verbal Learning TestImmediate Recall; RCF C, Rey Complex FigureCopy; RCF IR, Rey Complex FigureImmediate Recall 12 , 13 ; SD, standard deviation; SE, standard error; STEP, Estimation of Time and Weights Test 16 ; SVF, Semantic Verbal Fluency Test 13 . Or maybe it would be better just to put at the end of the whole text 15 , 16 , 17 , 18 .