FIGURE 2.

Age effects on (A) cortical gray matter, (B) deep gray matter, and (C) CSF volumes. Generalized linear mixed models showed that age was negatively associated with (A) cortical (β = –73.14, standard error [SE] = 23.60; t = –3.100; P = .003) and (B) deep gray matter volumes (β = –29.26, SE = 7.81, t = –3.749, P < .001). (C) There was a positive association between cerebrospinal fluid (CSF) volumes and age; CSF volumes were larger in older‐aged animals (β = 74.42, SE = 25.16; t = 2.96; P = .005). Each subject is represented by a distinct color, and the gray connecting lines indicate repeated scans