Table 3.
Allelic and genotypic frequency in MS patients and healthy controls
| SNP‡ | Additive model | Case/control | Allelic model | Case/control | Recessive model | Case/control | Dominant model | Case/control | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N freq | P value (chi-square) | Freq | P value (chi-square) | N freq | P value (chi-square) | N freq | P value (chi-square) | |||||
|
Beta-Fibrinogen rs#1,800,790 |
GG GA AA |
63 (55.75%)/38 (55.88%) 36 (31.85%)/29 (42.64%) 14 (12.38%)/1 (1.47%) |
0.024 |
G A |
71.68%/77.21% 28.3%/22.79% |
0.725 |
GG/GA AA |
99 (87.61%)/67 (98.53%) 14 (12.39%)/1 (1.47%) |
0.010 |
GG GA/AA |
63 (55.75%)/ 38 (55.88%) 50 (44.25%)/ 30 (44.12%) |
0.986 |
|
GpIIIa #rs5918 |
TT TC CC |
70 (67.96%)/48 (77.41%) 25 (24.27%)/12 (19.35%) 8 (7.76%)/2 (3.22%) |
0.298 |
T C |
80.1%/87.1% 19.9%/12.9% |
0.129 |
TT/TC CC |
93 (92.08%)/60 (96.77%) 8 (7.92%)/2 (3.23%) |
0.225 |
TT TC/CC |
68 (67.33%)/ 48 (77.42%) 33 (32.67%)/14 (22.58%) |
0.167 |
|
Factor V Leiden rs#6025 |
GG GA AA |
N/A | N/A |
G A |
97.9%/97.79% 2.1%/2.21% |
0.955 |
GG/GA AA |
N/A | N/A |
GG GA/AA |
114 (95.8%)/65 (95.59%) 5 (4.20%)/3 (4.41%) |
0.946 |
|
Factor V H2R #rs1800595 |
HH HR RR |
N/A | N/A | HR |
91.53%/96.97% 8.47%/3.03% |
0.540 |
HH/HR RR |
N/A | N/A |
HH HR/RR |
99 (83.90%)/62 (93.94%) 19 (16.10)/4 (6.06) |
0.048 |
|
Prothrombin 20,210 G/A rs#1,799,963 |
GG GA AA |
N/A | N/A |
G A |
95.8%/98.53% 4.2%/1.47% |
0.145 |
GG/GA AA |
N/A | N/A |
GG GA/AA |
109 (91.60%)/66 (97.06%) 10 (8.40%)/2 (2.94%) |
0.143 |
SNP, single-nucleotide polymorphism; A, adenine; C, cytosine; G, guanine; GpIIIa, glycoprotein IIIa; H, histidine; R, arginine; rs, reference sequence; T, thymine