Table 4.

Cumulative genetic risk score (CGRS) in MS patients compared to controls

Ordered logistic regression
	Adjusted OR		p value		[95% conf. interval]
Multiple sclerosis	2.217		0.010		1.207–4.069
1 risk allele	− 0.203		-		− 1.187–0.780
2 risk alleles	1.431		-		0.424–2.439
3 risk alleles	3.169		-		2.030–4.307
4 risk alleles	4.632		-		3.123–6.141
Multinomial logistic regression
Risk alleles	Adjusted RRR			p value	[95% conf. interval]
0	Base outcome
1–2	2.193			0.031	1.075–4.472
3–4	8.360			0.047	1.497–107.503
Test for trend
Risk alleles	OR	p value				[95% conf. interval]
0–1	1	-				-
2	2.106	0.0354				1.035–4.283
3–4	12.913	0.0046				1.301–128.122
P trend: 0.002

OR, odds ratio; RRR, relative risk ratio