Table 4. Univariate and multivariate Cox-regression results of factors related to overall survival based on TCGA.

Univariate analysis				Multivariate analysis
Variables		Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Age	<50	1.000 (reference)		1.000 (reference)
	50–59	1.190(0.815–1.737)	0.369	1.190(0.801–1.769)	0.389
	60–69	1.172(0.812–1.693)	0.397	1.274(0.871–1.862)	0.212
	70–79	0.682(0.4375–1.063)	0.091	0.660(0.411–1.059)	0.085
	≥80	1.098(0.393–3.067)	0.858	1.420(0.494–4.084)	0.516
Gender	Female	1.000 (reference)	–	1.000 (reference)	–
	Male	1.362(1.018–1.822)	0.038	1.274(0.925–1.756)	0.139
Pathologic grade	G1	1.000 (reference)		1.000 (reference)
	G2	0.989(0.664–1.474)	0.958	1.207(0.791–1.842)	0.384
	G3	0.949(0.623–1.444)	0.806	1.149(0.731–1.806)	0.549
	G4	1.384(0.632–3.031)	0.806	1.331(0.576-3.078)	0.503
Pathologic stage	Stage I	1.000 (reference)	–	1.000 (reference)	–
	Stage II	1.109(0.809–1.519)	0.520	1.203(0.869–1.667)	0.266
	Stage III	0.790(0.559–1.117)	0.183	0.904(0.633–1.291)	0.580
	Stage IV	0.886(0.124–6.357)	0.904	1.333(0.180–9.894)	0.779
New tumor event after initial treatment	No	1.000 (reference)	–	1.000 (reference)	–
	Yes	0.548(0.420–0.715)	<0.001	0.522(0.396–0.688)	<0.001
Alcohol history	No	1.000 (reference)	–	1.000 (reference)	–
	Yes	1.169(0.886–1.542)	0.268	1.140(0.842–1.544)	0.397