Table 3.

Multiple regression model for prediction of age at onset

	Whole cohort		Women		Men
	B (95% CI)	β	B (95% CI)	β	B (95% CI)	β
(Constant)	33.11 (2.02:64.21)		39.68 (8.59:70.77)		− 42.87 (− 137.59:51.85)
Sex (F = 1, M = 0)	− 0.07 (− 3.69:3.55)	− 0.004	–	–	–	–
Years of education	− 0.93*** (− 1.35: − 0.51)	− 0.49	− 1.13*** (− 1.58: − 0.68)	− 0.60	− 0.55 (− 1.62:0.51)	− 0.26
TIB	0.43** (0.16:0.70)	0.39	0.38* (0.10:0.65)	0.34	1.20* (0.24:2.16)	0.63
APOE ɛ4 +	1.84 (− 1.31:5.00)	0.10	0.25 (− 3.43:3.95)	0.13	4.69 (− 1.38:10.77)	0.27
HDRS	0.05 (− 0.29:0.39)	0.026	− 0.09 (− 0.48:0.29)	− 0.49	− 0.28 (− 1.15:0.58)	− 0.15
MMSE	− 0.47 (− 1.24:0.30)	− 0.49	− 0.38 (− 1.23:0.48)	− 0.60	− 1.11 (− 2.94:0.71)	− 0.26

B, unstandardized regression coefficient; β, standardized coefficient. All the covariates included in the analysis are reported. Age at onset was considered as a dependent variable. *p < 0.05, **p < 0.005, and ***p < 0.001