Table 3.
Association between annual DCCT early rapid eGFR loss and EDIC outcomes, using Cox proportional hazards models stratified by number of DCCT eGFR measurements
| Unadjusted | Adjusted* | Further adjusted* for adult/adolescent | Further adjusted* for DCCT closeout eGFR | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Early rapid eGFR loss | ||||||||
| CVD | 1.05 (0.67, 1.62) | 0.8393 | 1.04 (0.66, 1.62) | 0.8697 | 1.05 (0.67, 1.63) | 0.8462 | 1.03 (0.64, 1.67) | 0.9008 |
| MACE | 1.54 (0.87, 2.72) | 0.1408 | 1.60 (0.89, 2.87) | 0.1142 | 1.61 (0.90, 2.89) | 0.1068 | 1.51 (0.79, 2.90) | 0.2115 |
| eGFR <60 mL/min/1.73 m2 | 1.91 (1.26, 2.90) | 0.0023 | 1.84 (1.20, 2.81) | 0.0048 | 1.82 (1.18, 2.78) | 0.0062 | 0.94 (0.53, 1.66) | 0.8401 |
| DCCT closeout eGFR | ||||||||
| CVD | 0.99 (0.98, 0.99) | 0.0012 | 1.00 (0.99, 1.01) | 0.9007 | 1.00 (0.99, 1.01) | 0.9095 | 1.00 (0.99, 1.01) | 0.9514 |
| MACE | 0.98 (0.97, 0.99) | 0.0069 | 0.99 (0.97, 1.01) | 0.3062 | 0.99 (0.97, 1.01) | 0.3162 | 1.00 (0.98, 1.02) | 0.7107 |
| eGFR <60 mL/min/1.73 m2 | 0.97 (0.96, 0.98) | <0.0001 | 0.96 (0.95, 0.98) | <0.0001 | 0.96 (0.95, 0.98) | <0.0001 | 0.96 (0.95, 0.98) | <0.0001 |
Bold values are statistically significant.
*
Adjusted for current age, current BMI, current duration, sex, mean updated HbA1c, group, and cohort.