Table 2.
Results of pPS on outcomes that reached study-wide significance
| Without T2D adjustment | With T2D adjustment | ||||
|---|---|---|---|---|---|
| Cluster | Outcome | Effect estimate per average pPS allele | P value | Effect estimate per average pPS allele | P value |
| Obesity | SBP | 0.68 mmHg | 8.1 × 10−17 | 0.56 | 7.9 × 10−11 |
| Obesity | DBP | 0.44 mmHg | 1.9 × 10−19 | 0.38 | 1.5 × 10−13 |
| Obesity | Hypertension | OR 1.08 | 1.1 × 10−18 | 1.07 | 1.3 × 10−11 |
| Lipodystrophy | SBP | 2.43 mmHg | 8.9 × 10−39 | 1.8 | 4.7 × 10−20 |
| Lipodystrophy | DBP | 0.95 mmHg | 1.8 × 10−17 | 0.73 | 6.9 × 10−10 |
| Lipodystrophy | Hypertension | OR 1.30 | 1.3 × 10−34 | 1.20 | 6.8 × 10−15 |
| Lipodystrophy | CAD | OR 1.32 | 1.5 × 10−08 | 1.11 | 5.8 × 10−02 |
| Liver/lipid | CAD | OR 0.94 | 2.7 × 10−03 | 0.92 | 1.2 × 10−04 |
| Liver/lipid | eGFR | −0.87 mL/min | 5.0 × 10−78 | −0.81 | 9.4 × 10−61 |
| Liver/lipid | CKD | OR 1.08 | 1.5 × 10−04 | 1.06 | 2.1 × 10−02 |
| β-Cell | SBP | 1.43 mmHg | 3.6 × 10−11 | 0.35 | 1.3 × 10−01 |
| β-Cell | DBP | −0.13 mmHg | 3.1 × 10−01 | −0.61 | 9.3 × 10−06 |
| β-Cell | HTN | OR 1.15 | 2.6 × 10−08 | 1.00 | 8.6 × 10−01 |
| β-Cell | CAD | OR 1.41 | 1.7 × 10−09 | 1.12 | 7.7 × 10−02 |
| Proinsulin | DBP | −0.18 mmHg | 4.4 × 10−03 | −0.25 | 1.8 × 10−04 |
Cluster-outcome models with a significantly associated pPS. Effect estimates are in terms of outcome units per average weighted alleles in the pPS. Bold indicates a significant result at the 0.0005 Bonferroni-corrected threshold.