Plasma metabolic profiles among patients with DM with and without CVD and the control group using PCA and each metabolite related with the risk of CVD in patients with diabetes. A: The score plots show a statistically significant difference in data between the DM and NGT groups, indicating significant biochemical changes caused by hyperglycemia. Furthermore, there was a clear separation between DM_CVD and DM_non-CVD, indicating that metabolites can differentiate diabetes with and without CVD. B: Association between each metabolite and CVD in diabetes after adjustment for age, sex, smoking, BMI, SBP, FPG, and TC. PC, glycerophosphocholine. ‡Per 0.01-unit increase; §per 0.1-unit increase; ǁper 10-unit increase.