Table 2.
Cox regression analysis for association between baseline relative telomere length and glycemic progression defined as need for insulin treatment
| Variables | Unadjusted model | Fully adjusted model | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| rLTL | 1.098 (1.056–1.142) | <0.001 | 1.052 (1.007–1.100) | 0.023 |
| Age at diagnosis (per 1 year) | 0.971 (0.966–0.976) | <0.001 | ||
| Duration of diabetes (per 1 year) | 1.020 (1.011–1.029) | <0.001 | ||
| Smoking | ||||
| Non-smoker | Reference | |||
| Ex-smoker | 1.247 (1.088–1.430) | 0.002 | ||
| Current smoker | 1.158 (1.003–1.337) | 0.045 | ||
| Log (TG) | 1.323 (1.044–1.675) | 0.020 | ||
| LDL-C | 0.936 (0.886–0.987) | 0.015 | ||
| Log urinary ACR | 1.373 (1.262–1.495) | <0.001 | ||
| eGFR | 0.991 (0.988–0.994) | <0.001 | ||
| Sensory neuropathy | 1.268 (1.120–1.435) | <0.001 | ||
| Retinopathy | 1.235 (1.092–1.396) | 0.001 | ||
| Use of OGLD | 1.284 (1.143–1.443) | <0.001 | ||
| Use of lipid-lowering drugs | 1.049 (0.901–1.221) | 0.541 | ||
| Use of RAS inhibitors | 1.147 (0.999–1.318) | 0.052 | ||
BMI and baseline HbA1c categories were included as strata variables. BMI was categorized as four groups (<18.5, 18.5–23, 23–25, and ≥25 kg/m2), and baseline HbA1c was categorized as three groups (<7%, ≥7–9%, and ≥9%).
RAS, renin-angiotensin system. Boldface indicate P values < 0.05.