Table 1.
Summary of recent major preclinical studies of stem cells using rodent hemorrhagic stroke models over the past 5 years
| Study | Type | Model | Species | Stem cell source | Dosage | Volume (μL) | Timing | Delivery route |
|---|---|---|---|---|---|---|---|---|
| Chen et al. [11] (2020) | ICH | Coll | Rat | rBMSCs | 2×106 cells | 2 | 1 day | IC |
| Mello et al. [45] (2020) | ICH | Coll | Rat | hUC-MSCs | 3×106 cells | 500 | 1 day | IV |
| Huang et al. [28] (2019) | ICH | ABI | Rat | hBMSCs | 2×105, 5×105, 10×105/kg cells | N.C | 0.5 hours | IV |
| Deng et al. [17] (2019) | ICH | Coll | Rat | rBMSCs, GDNF overexpression | 5×105 cells | 20 | 3 day | IC |
| Han et al. [24] (2018) | ICH | ABI | Rat | rBMSC-derived exosomes | 100 μg of exosome | 500 | 1 day | IV |
| Zhang et al. [71] (2019) | ICH | Coll | Mouse | rASCs | 3–4×105 cells | 3 | 2 days | IC |
| Li et al. [41] (2019) | ICH | Coll | Mouse | rASCs, CX3CR1 overexpression | 2–4×05 cells | 2 | 3 days | IC |
| Kuramoto et al. [36] (2019) | ICH | Coll | Mouse | hASCs | 1×106 cells | 100 | 1 day | IV |
| Kim et al. [32] (2020) | IVH | ABI | Rat | hUC-MSCs | 1×105 cells | 10 | 2 days | IC |
| Zhang et al. [69] (2018) | ICH | Coll | Rat | rBMSC, miR21 overexpression | 1×106 cells | 10 | 0.5 hours | IC |
| Choi et al. [12] (2018) | ICH | Coll | Rat | hPSCs (placenta) | 1×106 cells | 500 | 1 hour | IV |
| Min et al. [46] (2018) | ICH | Coll | Rat | hPSCs (placenta) | 2.5×106 cells | N.C | 1 day | IV |
| Cui et al. [16] (2017) | ICH | ABI | Rat | rBMSCs | 5×103 cells | 100 | 1 day | IV |
| Cui et al. [15] (2017) | ICH | ABI | Rat | rBMSCs, CM | 10 μL of conditioned media | 10 | 0 hour | IV |
| Xie et al. [67] (2016) | ICH | Coll | Rat | hUC-MSCs | 2×105, 2×106 cells | 10, 1000 | N.C | IC, IV |
| Qin et al. [50] (2015) | ICH | Coll | Rat | iPSCs | 1×106 cells | 10 | 6 hours | IC |
| Han et al. [23] (2021) | SAH | EVP | Rat | rBMSC-derived exosome | 100 μg of exosome | 500 | 10 minutes | IV |
| Xiong et al. [68] (2020) | SAH | EVP | Rat | rBMSC-derived exosome | 200 μg of exosome | 200 | 5 minutes | IV |
| Chen et al. [9] (2020) | SAH | ABI | Rat | hUC-MSC, KO-TGF-b1 | 1×105 cells | N.C. | -1, 10 days | IC |
| Liu et al. [43] (2019) | SAH | EVP | Rat | rBMSC | 3×106 cells | 1000 | 1, 3 days | IV |
| Zhao et al. [72] (2019) | SAH | ABI | Rat | hUC-MSC-derived exosome | 400 μg of exosome | 200 | 1 hour | IV |
| Nijboer et al. [47] (2018) | SAH | EVP | Rat | rBMSC | 1.5×106 cells | 24 | 6 days | IN |
ICH : intracerebral hemorrhage, Coll : collagenase injection, r : rat, BMSCs : bone marrow mesenchymal stem cells, IC : intracerebral, h : human, UC-MSCs : umbilical cord-derived mesenchymal stem cells, IV : intravenous, ABI : autologous blood injection, N.C : no comment, GDNF : glial cell-derived neurotrophic factor, ASCs : adipose-derived mesenchymal stem cells, IVH : intraventricular hemorrhage, PSCs : placenta-derived mesenchymal stem cells, CM : conditioned medium, iPSCs : induced pluripotent stem cells, SAH : subarachnoid hemorrhage, EVP : endovascular perforation, IN : intranasal