Table 2.

Cord blood DNAm associations with maternal glycemic traits (P value <1.0 × 10⁻⁶)

Glycemic trait	Probe identifier	Position (hg19)	Nearest gene	Restricting to fasting participants				Including nonfasting participants
				N	β (SE)	P †	I 2	N	β (SE)	P †	I 2
Glucose	cg26104143	chr4: 41869579	TMEM33	2,404	−0.26 (0.04)	7.9 × 10−9	42.7	3,503	−0.18 (0.033)	1.1 × 10−7	62.2
Glucose	cg26974062	chr1: 145440734	TXNIP	1,056	−3.0 (0.56)	3.0 × 10−7	0	1,056	−3.0 (0.56)	2.6 × 10−7	0
Glucose	cg21686486	chr2: 172377802	CYBRD1	1,056	1.2 (0.22)	3.2 × 10−7	57.4	1,056	1.2 (0.22)	2.8 × 10−7	57.4
Insulin	cg21139325	chr6: 32729470	HLA-DQB2	961	0.55 (0.11)	2.8 × 10−7	0	2,062	0.16 (0.029)	3.1 × 10−7	15.2
AUCgluc	cg26974062	chr1: 145440734	TXNIP	953	−0.013 (2.1 × 10−3)	6.3 × 10−9	52.1
AUCgluc	cg02988288	chr1: 145440445	TXNIP	953	−0.013 (2.3 × 10−3)	7.9 × 10−8	60.4
AUCgluc	cg09049566	chr5: 132165605	SHROOM1	1,505	−2.0 × 10−3 (3.9 × 10−4)	9.2 × 10−7	1.9

Overview of the meta-analysis results with a P value <1.0 × 10⁻⁶ after correction for inflation/bias with the bacon R package. The used rlm with robust SEs was as follows: β value ˜ glycemic trait + GA at maternal sampling + sex of the child + imputed cord blood cell proportions + maternal age + GA at birth + parity and cohort-specific (technical) variables.

^†P value after correction for inflation and bias with the bacon R package. Correction is based on the entire distribution of test statistics of each meta-analysis and may therefore (slightly) differ between the fasted and combined meta-analyses as the sample size is increased for many CpGs.