Table 3.
Cross-sectional associations of blood DNAm at cg02988288 and metabolic phenotypes in childhood and adulthood
| TEENDIAB participants (German Europeans ages 4–19 years [49.6% female])§ | NFBC1966 participants (Finnish Europeans ages 46 years [56% female])† | |||||
|---|---|---|---|---|---|---|
| β (SE) | P | N | β (SE) | P | N | |
| Fasting plasma glucose (mmol/L) | −0.37 (0.30) | 0.22 | 366 | −0.71 (0.16) | 1.20 × 10−5 | 680 |
| Fasting plasma insulin (pmol/L) | −0.41 (0.17) | 0.014 | 369 | −0.044 (0.013) | 9.9 × 10−4 | 685 |
| AUCgluc (mmol/L*min) | −1.4 × 10−3 (1.5 × 10−3) | 0.33 | 232 | −2.1 × 10−3 (6.5 × 10−4) | 1.3 × 10−3 | 589 |
| BMI (kg/m2) | −7.3 × 10−2 (5.3 × 10−2) | 0.17 | 383 | −0.077 (0.022) | 5.0 × 10−4 | 693 |
| Body fat (bio-impedence) | NA | NA | NA | −0.039 (0.014) | 4.3 × 10−3 | 671 |
| Waist-to-hip ratio | −0.14 (0.17) | 0.42 | 365 | NA | NA | NA |
| HOMA-IR | −0.29 (8.4 × 10−2) | 5.0 × 10−4 | 365 | NA | NA | NA |
| HbA1c (mmol/L) | −8.5 × 10−3 (4.7 × 10−2) | 0.85 | 361 | −0.090 (0.024) | 2.6 × 10−4 | 693 |
| Type 2 diabetes | NA | NA | NA | −1.46 (0.52) | 4.7 × 10−3 | 507 |
HOMA-IR, HOMA of insulin resistance. NA, not available for assessment.
§
Outcome of analyses in the TEENDIAB cohort. Columns denote the results from an rlm with robust SEs adjusting for sex, age at blood draw, batch, imputed cell heterogeneity, maternal type 1 diabetes status, and parental socioeconomic status.
†
Outcome of analyses in NFBC1966. The results from an rlm with robust SEs adjusting for sex, batch, imputed cell proportions, and socioeconomic status.