Table 3.
One-month and 1-year mortality rate, univariate and multivariate analyses of the risk of death (Hazard Ratio) depending on presence of bacteraemia, age group, sex, qSOFA score, renal function and natremia
| Variable | Follow-up length, daysa | Mortality Rateb | 95% CI | Crude analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | Adjusted HR | 95% CI | p value | ||||
| One-month follow-up | |||||||||
| Exposure | |||||||||
| Bacteraemia | 23.36 | 3.08 | (2.47–3.85) | 1.53 | (1.07–2.20) | 0.021* | 1.30 | (0.90–1.88) | 0.16 |
| Controls | 24.77 | 1.97 | (1.26–2.24) | Ref | Ref | ||||
| Age group | |||||||||
| ≥ 90 years | 10.50 | 3.71 | (2.59–4.88) | 1.66 | (1.14–2.44) | 0.009* | 1.49 | (1.01–2.19) | 0.044* |
| 80–89 years | 37.63 | 2.17 | (1.71–2.65) | Ref | Ref | ||||
| Gender | |||||||||
| Men | 21.35 | 2.90 | (2.18–3.63) | 1.29 | (0.91–1.85) | 0.15 | |||
| Women | 26.77 | 2.20 | (1.63–2.74) | Ref | |||||
| qSOFA | |||||||||
| ≥ 2 | 6.35 | 8.34 | (6.10–10.59) | 4.60 | (3.21–6.60) | < 0.001* | 3.87 | (2.64–5.78) | < 0.001* |
| < 2 | 41.78 | 1.62 | (1.24–2.01) | Ref | Ref | ||||
| Kidney injury* | |||||||||
| Yes | 33.56 | 2.74 | (2.18–3.30) | 1.36 | (9.00–2.07) | 0.096 | |||
| No | 14.57 | 1.99 | (1.27–2.71) | Ref | |||||
| Sodium | |||||||||
| > 145 mmol/L | 3.38 | 7.08 | (4.25–9.92) | 2.97 | (1.90–4.65) | < 0.001* | 1.76 | (1.09–2.83) | 0.019* |
| ≤ 145 mmol/L | 44.74 | 2.16 | (1.74–2.60) | Ref | Ref | ||||
| One-year follow-up | |||||||||
| Exposure | |||||||||
| Bacteraemia | 218.93 | 0.69 | (0.58–0.80) | 1.42 | (1.12–1.81) | 0.004* | 1.31 | (1.03–1.67) | 0.029* |
| Controls | 249.37 | 0.46 | (0.39–0.56) | Ref | Ref | ||||
| Age group | |||||||||
| ≥ 90 years | 96.23 | 0.83 | (0.65–1.01) | 1.56 | (1.20–2.03) | 0.001* | 1.53 | (1.17–1.99) | 0.002* |
| 80–89 years | 372.04 | 0.51 | (0.44–0.58) | Ref | Ref | ||||
| Gender | |||||||||
| Men | 203.24 | 0.65 | (0.53–0.76) | 1.21 | (0.95–1.53) | 0.12 | |||
| Women | 265.02 | 0.52 | (0.43–0.61) | Ref | |||||
| qSOFA | |||||||||
| ≥ 2 | 49.48 | 1.60 | (1.24–1.95) | 2.98 | (2.98–3.88) | < 0.001* | 2.71 | (2.05–3.57) | < 0.001* |
| < 2 | 418.78 | 0.81 | (0.71–0.94) | Ref | Ref | ||||
| Kidney injury* | |||||||||
| Yes | 327.64 | 1.27 | (1.10–1.46) | 1.20 | (0.91–1.57) | 0.19 | |||
| No | 140.62 | 2.58 | (2.04–3.25) | Ref | |||||
| Sodium | |||||||||
| > 145 mmol/L | 29.81 | 1.14 | (0.76–1.52) | 1.94 | (1.35–2.78) | < 0.001* | 1.37 | (0.94–1.99) | 0.10 |
| ≤ 145 mmol/L | 438.45 | 0.54 | (0.47–0.60) | Ref | Ref | ||||
CI confidence interval
*Kidney injury is estimated glomerular filtration rate < 60 mL/min HR: hazard Ratio. qSOFA: quick Systematic Organ Failure Assessment. eGFR: estimated glomerular filtration rate. aMeasured in person years. bRate per 1 person-year