Table 1.
Clinicopathological characteristics of patients with SCRC and PCRC
| Overall | SCRC | PCRC | P valueb | |
|---|---|---|---|---|
| N = 1554 | N = 422 | N = 1132 | ||
| Sex (%) | ||||
| Female | 564 (36.29) | 126 (29.86) | 438 (38.69) | 0.002 |
| Male | 990 (63.71) | 296 (70.14) | 694 (61.31) | |
| EOCRC or LOCRC (%) | ||||
| LOCRC | 1233 (79.34) | 358 (84.83) | 875 (77.30) | 0.001 |
| EOCRC | 321 (20.66) | 64 (15.17) | 257 (22.70) | |
| Age (yrs) (median [IQR]) | 61.00 [52.00, 68.00] | 63.00 [55.00, 70.75] | 60.00 [51.00, 68.00] | < 0.001a |
| Family history of tumours (%) | ||||
| No | 1497 (96.33) | 399 (94.55) | 1098 (97.00) | 0.033 |
| Yes | 57 (3.67) | 23 (5.45) | 34 (3.00) | |
| BMI (kg/m2) (%) | ||||
| 18.5 to 24 | 927 (59.65) | 252 (59.72) | 675 (59.63) | 0.364 |
| < 18.5 | 152 (9.78) | 48 (11.37) | 104 (9.19) | |
| ≥ 24 | 475 (30.57) | 122 (28.91) | 353 (31.18) | |
| Hemoglobin (g/L) (%) | ||||
| > 110 | 1063 (68.40) | 259 (61.37) | 804 (71.02) | < 0.001 |
| ≤ 100 | 491 (31.60) | 163 (38.63) | 328 (28.98) | |
| Platelet counts (109/L) (%) | ||||
| ≤ 300 | 1122 (72.20) | 289 (68.48) | 833 (73.59) | 0.053 |
| > 300 | 432 (27.80) | 133 (31.52) | 299 (26.41) | |
| WBC (109/L) (%) | ||||
| ≤ 10 | 1441 (92.73) | 388 (91.94) | 1053 (93.02) | 0.537 |
| > 10 | 113 (7.27) | 34 (8.06) | 79 (6.98) | |
| CEA (ng/mL) (%) | ||||
| ≤ 10 | 1157 (74.45) | 297 (70.38) | 860 (75.97) | 0.029 |
| > 10 | 397 (25.55) | 125 (29.62) | 272 (24.03) | |
| CA199 (kU/L) (%) | ||||
| ≤ 27 | 1225 (78.83) | 320 (75.83) | 905 (79.95) | 0.090 |
| > 27 | 329 (21.17) | 102 (24.17) | 227 (20.05) | |
| CA125 (kU/L) (%) | ||||
| ≤ 35 | 1428 (91.89) | 383 (90.76) | 1045 (92.31) | 0.371 |
| > 35 | 126 (8.11) | 39 (9.24) | 87 (7.69) | |
| CA153 (kU/L) (%) | ||||
| ≤ 25 | 1526 (98.20) | 415 (98.34) | 1111 (98.14) | 0.965 |
| > 25 | 28 (1.80) | 7 (1.66) | 21 (1.86) | |
| AFP (ng/mL) (%) | ||||
| ≤ 7 | 1488 (95.75) | 402 (95.26) | 1086 (95.94) | 0.656 |
| > 7 | 66 (4.25) | 20 (4.74) | 46 (4.06) | |
| Type of ascites (%) | ||||
| No | 1453 (93.50) | 389 (92.18) | 1064 (93.99) | 0.398 |
| Serous | 90 (5.79) | 30 (7.11) | 60 (5.30) | |
| Bloody | 11 (0.71) | 3 (0.71) | 8 (0.71) | |
| Tumor location (%) | ||||
| Right colon | 321 (20.66) | 81 (19.19) | 240 (21.20) | < 0.001 |
| Left colon | 436 (28.06) | 93 (22.04) | 343 (30.30) | |
| Rectum | 659 (42.41) | 110 (26.07) | 549 (48.50) | |
| Multiple segment | 138 (8.88) | 138 (32.70) | 0 (0.00) | |
| Radical or palliative surgery (%) | ||||
| Palliative | 185 (11.90) | 61 (14.45) | 124 (10.95) | 0.071 |
| Radical | 1369 (88.10) | 361 (85.55) | 1008 (89.05) | |
| (y)pTNM staging (%) | ||||
| 0–I | 205 (13.19) | 51 (12.09) | 154 (13.60) | 0.001 |
| II | 572 (36.81) | 130 (30.81) | 442 (39.05) | |
| III | 533 (34.30) | 152 (36.02) | 381 (33.66) | |
| IV | 244 (15.70) | 89 (21.09) | 155 (13.69) | |
| Number of retrieved lymph nodes (%) | ||||
| < 12 | 165 (10.62) | 26 (6.16) | 139 (12.28) | 0.001 |
| ≥ 12 | 1389 (89.38) | 396 (93.84) | 993 (87.72) | |
| Gross classification (%) | ||||
| Mass type | 583 (37.52) | 168 (39.81) | 415 (36.66) | 0.138 |
| Infiltration type | 13 (0.84) | 6 (1.42) | 7 (0.62) | |
| Ulceration type | 958 (61.65) | 248 (58.77) | 710 (62.72) | |
| Histological type (%) | ||||
| Classical adenocarcinoma | 1452 (93.44) | 391 (92.65) | 1061 (93.73) | 0.663 |
| Mucinous adenocarcinoma | 97 (6.24) | 29 (6.87) | 68 (6.01) | |
| Signet ring cell carcinoma | 5 (0.32) | 2 (0.47) | 3 (0.27) | |
| Differentiation grade (%) | ||||
| Well differentiated | 230 (14.80) | 59 (13.98) | 171 (15.11) | 0.404 |
| Moderately differentiated | 1096 (70.53) | 293 (69.43) | 803 (70.94) | |
| Poorly differentiated | 228 (14.67) | 70 (16.59) | 158 (13.96) | |
| Vessel invasion (%) | ||||
| Negative | 1294 (83.27) | 339 (80.33) | 955 (84.36) | 0.069 |
| Positive | 260 (16.73) | 83 (19.67) | 177 (15.64) | |
| Neural invasion (%) | ||||
| Negative | 1243 (79.99) | 339 (80.33) | 904 (79.86) | 0.892 |
| Positive | 311 (20.01) | 83 (19.67) | 228 (20.14) | |
| Ki67 expression (%) | ||||
| Low | 95 (6.11) | 28 (6.64) | 67 (5.92) | 0.616 |
| Moderate | 204 (13.13) | 60 (14.22) | 144 (12.72) | |
| High | 1255 (80.76) | 334 (79.15) | 921 (81.36) | |
| MMR status (%) | ||||
| pMMR | 1424 (91.63) | 370 (87.68) | 1054 (93.11) | 0.001 |
| dMMR | 130 (8.37) | 52 (12.32) | 78 (6.89) | |
| Alive status (%) | ||||
| Alive | 1293 (83.20) | 338 (80.09) | 955 (84.36) | 0.054 |
| Death | 261 (16.80) | 84 (19.91) | 177 (15.64) | |
aIndependent samples Mann–Whitney U test; bThe bolded P value was statistically significant (P < 0.05)