Table 3.
Prognostic factors for overall survival of patient with CRC
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P valuea | HR (95%CI) | P valuea | |
| Gender | ||||
| Female | 1 | (Reference) | ||
| Male | 1.17 (0.90–1.51) | 0.235 | ||
| EOCRC or LOCRC | ||||
| LOCRC | 1 | (Reference) | 1 | (Reference) |
| EOCRC | 0.40 (0.27–0.59) | < 0.001 | 0.35 (0.24–0.53) | < 0.001 |
| Family history of tumours | ||||
| No | 1 | (Reference) | 1 | (Reference) |
| Yes | 0.34 (0.12–0.90) | 0.030 | 0.56 (0.20–1.53) | 0.257 |
| BMI (kg/m2) | ||||
| 18.5 to 24 | 1 | (Reference) | 1 | (Reference) |
| < 18.5 | 1.59 (1.12–2.27) | 0.009 | 1.82 (1.26–2.62) | 0.001 |
| ≥ 24 | 0.86 (0.65–1.15) | 0.314 | 1.05 (0.78–1.41) | 0.762 |
| Haemoglobin (g/L) | ||||
| > 110 | 1 | (Reference) | 1 | (Reference) |
| ≤ 100 | 1.62 (1.26–2.07) | < 0.001 | 1.38 (1.05–1.81) | 0.022 |
| Platelet counts (109/L) | ||||
| ≤ 300 | 1 | (Reference) | ||
| > 300 | 1.12 (0.85–1.47) | 0.414 | ||
| WBC (109/L) | ||||
| ≤ 10 | 1 | (Reference) | ||
| > 10 | 0.94 (0.59–1.49) | 0.783 | ||
| CEA (ng/mL) | ||||
| ≤ 10 | 1 | (Reference) | 1 | (Reference) |
| > 10 | 2.84 (2.22–3.64) | < 0.001 | 1.47 (1.11–1.94) | 0.006 |
| CA199 (kU/L) | ||||
| ≤ 27 | 1 | (Reference) | 1 | (Reference) |
| > 27 | 2.58 (2.01–3.32) | < 0.001 | 1.22 (0.91–1.62) | 0.186 |
| CA125 (kU/L) | ||||
| ≤ 35 | 1 | (Reference) | 1 | (Reference) |
| > 35 | 3.94 (2.89–5.36) | < 0.001 | 1.95 (1.36–2.79) | < 0.001 |
| CA153 (kU/L) | ||||
| ≤ 25 | 1 | (Reference) | 1 | (Reference) |
| > 25 | 2.94 (1.51–5.73) | 0.002 | 2.31 (1.13–4.73) | 0.022 |
| AFP (ng/mL) | ||||
| ≤ 7 | 1 | (Reference) | ||
| > 7 | 0.81 (0.41–1.57) | 0.527 | ||
| Type of ascites | ||||
| No | 1 | (Reference) | 1 | (Reference) |
| Serous | 1.53 (1.00–2.35) | 0.051 | 0.72 (0.45–1.16) | 0.179 |
| Bloody | 5.40 (2.67–10.94) | < 0.001 | 2.86 (1.29–6.34) | 0.010 |
| Tumor location | ||||
| Right colon | 1 | (Reference) | 1 | (Reference) |
| Left colon | 0.66 (0.46–0.93) | 0.018 | 0.70 (0.48–1.02) | 0.067 |
| Rectum | 0.74 (0.54–1.01) | 0.057 | 1.02 (0.72–1.44) | 0.909 |
| Multiple segment | 0.85 (0.54–1.35) | 0.496 | 0.76 (0.44–1.32) | 0.326 |
| Radical or palliative surgery | ||||
| Radical | 1 | (Reference) | 1 | (Reference) |
| Palliative | 9.49 (7.37–12.23) | < 0.001 | 3.99 (2.42–6.56) | < 0.001 |
| (y)pTNM staging | ||||
| 0–I | 1 | (Reference) | 1 | (Reference) |
| II | 0.92 (0.63–1.35) | 0.672 | 0.70 (0.48–1.02) | 0.067 |
| III | 0.82 (0.56–1.21) | 0.314 | 1.02 (0.72–1.44) | 0.908 |
| IV | 1.02 (0.66–1.56) | 0.933 | 0.76 (0.44–1.32) | 0.326 |
| Number of retrieved lymph nodes | ||||
| < 12 | 1 | (Reference) | 1 | (Reference) |
| ≥ 12 | 1.57 (1.14–2.16) | 0.006 | 1.43 (1.02–2.00) | 0.041 |
| Gross classification | ||||
| Mass type | 1 | (Reference) | 1 | (Reference) |
| Infiltration type | 3.05 (1.24–7.51) | 0.015 | 1.14 (0.40–3.23) | 0.802 |
| Ulceration type | 1.06 (0.82–1.37) | 0.655 | 0.82 (0.62–1.08) | 0.160 |
| Histological type | ||||
| Classical adenocarcinoma | 1 | (Reference) | ||
| Mucinous adenocarcinoma | 1.03 (0.65–1.62) | 0.915 | ||
| Signet ring cell carcinoma | 0 (0-Inf) | 0.990 | ||
| Differentiation grade | ||||
| Well differentiated | 1 | (Reference) | 1 | (Reference) |
| Moderately differentiated | 1.26 (0.91–1.77) | 0.167 | 1.06 (0.75–1.49) | 0.759 |
| Poorly differentiated | 1.93 (1.29–2.89) | 0.001 | 1.30 (0.83–2.04) | 0.252 |
| Vessel invasion | ||||
| Negative | 1 | (Reference) | 1 | (Reference) |
| Positive | 2.62 (1.98–3.48) | < 0.001 | 1.44 (1.03–2.01) | 0.033 |
| Neural invasion | ||||
| Negative | 1 | (Reference) | 1 | (Reference) |
| Positive | 2.07 (1.56–2.73) | < 0.001 | 1.04 (0.75–1.43) | 0.824 |
| Ki67 expression | ||||
| Low | 1 | (Reference) | ||
| Moderate | 0.81 (0.48–1.37) | 0.429 | ||
| High | 0.84 (0.54–1.32) | 0.459 | ||
| MMR status | ||||
| pMMR | 1 | (Reference) | 1 | (Reference) |
| dMMR | 0.45 (0.25–0.80) | 0.007 | 0.67 (0.36–1.27) | 0.221 |
| Tumor type | ||||
| PCRC | 1 | (Reference) | 1 | (Reference) |
| SCRC | 1.36 (1.05–1.76) | 0.021 | 1.02 (0.75–1.40) | 0.889 |
HR hazard ratio, CI confidence interval. aThe bolded P value was statistically significant (P < 0.05)