Table 5.
Comparison between literature studies: External beam radiatilon therapy associated to high dose rate brachytherapy in the treatment of localized Prostate Cancer-low (L), intermediate (I) and high (H) risk
| Authors | Study Design | Patients (n) | Total HDR BT dose (Gy) | Gy/fractionation | Total EBRT dose (Gy) | Follow-up (years) | Recurrence free (%) | 3rd or 4th degree late toxicity (%) | Erectile preservation (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||||
| Low | Intermediate | High | GU | GI | ||||||||
| Borghede (1997) | Prospective | 50 | 10 | 5 | 50 | 1.5 | 97 | 97 | 92 | 2 | 0 | 74 |
| Demanes (2005) | Prospective | 209 | 23 | 6 | 36 | 7.3 | 90 | 87 | 69 | 7.7 | 0 | 67 |
| Kalkner (2007) | Phase I | 154 | 20 | 10 | 50 | 6.1 | 97 | 83 | 83 | 5 | 1 | NA |
| Pellizzon (2008) | Phase II | 209 | 20 | 10 | 45 | 5.3 | 92 | 90 | 89 | NA | NA | NA |
| Demanes (2009) | Prospective | 211 | 23 | 6 | 36 | 6.4 | 92 | 87 | 63 | 0 | 0 | NA |
| Liu (2016) | Prospective | 156 | 18 | 9 | 39 | 3.1 | 100 | 100 | 96.9 | 2.6 | 0 | NA |
| This study | Retrospective | 162 | 8-20 | 8-10 | 45-66 | 4.75 | 96.5 | 96.2 | 96.2 | 0.6 | 0 | NA |
| Mean | 170 | 19.6 | 7.4 | 41.7 | 5.1 | 94.3 | 90.2 | 79.4 | 2.9 | 0.2 | 69.5 | |
EBRT: External beam radiation therapy; high dose rate brachytherapy (HDR-BT); BT: Brachytherapy; Gy: Radiation dose Unit (Gray); GU: genitourinary system; GI: gastrointestinal system; NA: not available.