TABLE 1.

Plasma artesunate concentrations in six patients with uncomplicated falciparum malaria

Patient no.	Plasma artesunate concn (μg · liter−1) at sampling time (h)
	0a	2	12a	14	24b	26c	96b	98	100	102	104	106	108	112	120
1	0	2	7	7	0	0	2	2	2	2	2	2	0	0	0
2	0	20	18	18	24	12	4	4	4	5	6	3	12	26	10
3	0	0	0	0	0	11	0	0	0	0	0	0	0	0	0
4	0	9	7	10	4	4	3	0	0	0	0	0	0	0	0
5	0	—d	16	20	12	50	12	—	12	10	—	0	0	0	0
6	0	10	7	16	6	9	—	4	—	—	—	4	4	4	0
Mean	0	8	9	12	8	14	4	2	4	4	3	1	3	5	2
SD	0	8	7	8	9	18	5	2	5	4	3	2	5	11	4

^aA 150-mg dose of artesunate was administered at this time. 

^bA 100-mg dose of artesunate was administered at this time. 

^cFor the two subsequent dosing periods (48 and 72 h), 100-mg doses of artesunate were administered but concentrations in plasma were not determined. 

^d—, missing value.