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. 2021 Mar 18;26(6):1826–1841. doi: 10.1111/jcmm.16454

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Analysis of microarray profile between PE and NP. A, Circos plot showing the differentially expressed circRNAs in human chromosomes (hg19). From the outside to inside represents NP 1‐5 and PE 1‐5. The values represent the log2 (fold change) of the two groups. B, Pie chart showing circRNA classes. C, Volcano plot of circRNAs. The red and blue points demonstrate the differentially expressed circRNAs with a greater than a two fold change. D, Cluster heat map of differentially expressed circRNAs with a greater than a twofold change in five paired PE and NP tissues. Red represents the up‐regulated circRNAs, and green represents the down‐regulated circRNAs. E, KEGG pathway enrichment of the parental genes of the differentially expressed circRNAs. The top 20 categories are exhibited. F, GO analysis of the parental genes of the differentially expressed circRNAs [Colour figure can be viewed at wileyonlinelibrary.com]