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. 2021 Feb 23;26(6):1806–1816. doi: 10.1111/jcmm.16166

FIGURE 5.

FIGURE 5

Circ_0002137 bond to miR‐433‐3p in OS cell line. A, Predicted binding sites between circ_0002137 and miR‐433‐3p using circInteractome (NIH, USA). B, Dual‐luciferase reporter assay was conducted to detect the interaction between circ_0002137 and miR‐433‐3p. C, RNA pull‐down assay was performed in order to verify the direct binding of circ_0002137 and miR‐433‐3p. D, The result of qRT‐PCR demonstrated higher level of miR‐433‐3p in OS tissue compared with normal tissue. E, The level of miR‐433‐3p was negatively related with circ_0002137