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. 2022 Mar 13;79(3):185. doi: 10.1007/s00018-022-04163-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — SPPL3 cleavage products detected in human blood proteome data. a Intramembrane cleavage sites inferred from neo-N-termini identified in degradome set of human serum. Cleavage sites mapped to select type II membrane protein Golgi GMEs are depicted. Grey arrows indicate SPPL3-depedent proteolytic events identified in this study (Fig. 2), red and blue arrowheads indicate cleavage sites observed in blood samples. b Intramembrane cleavage sites inferred from semi-tryptic peptides deposited in the Human Plasma PeptideAtlas (Build 2021-07). The deposited data were searched for Golgi GMEs that we found to undergo SPPL3-mediated intramembrane proteolysis in this study. Peptide accession numbers are compiled in the Suppl. Tables