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. 2022 Feb 28;28:1610233. doi: 10.3389/pore.2022.1610233

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Copyright © 2022 Mohamed, Kurdi, Baeesa, Sabbagh, Hakamy, Maghrabi, Alshedokhi, Dallol, Halawa, Najjar and Fdl-Elmula.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between Pan-Trk expression using IHC and NTRK-fusions detection using NGS. Pan-Trk expression was detected in 11 tumours and 12 tumours showed no Pan-Trk expression. Only two of the expressed cases (18%) were found to have NTRK2-fusions, and the remaining 9 Cases (82%) did not reveal any NTRK-fusions. The 12 cases with no Pan-Trk expression showed no NTRK-fusions. There was no statistically significant association between IHC and NGS in detecting NTRK-fusion (p > 0.05).