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. 2022 Mar 14;7:79. doi: 10.1038/s41392-022-00893-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Off-target analysis for RNA editing in 293T cells by RNA-Seq. a Off-target-1 to Off-target-10 are ten off-target sites detected by RNA-seq. Mismatches compared to the on-target site are shown and highlighted in color. The 30 bp sequence (On-target) targeted by the sgRNA3 is shown in the top row. b Off-target analysis for RNA editing in 293T cells by RNA-Seq. No significant difference was found in CasRx + sgRNA3 + mCherry-Tmc1^Bth, CasRx + sgRNA3 + mCherry-Tmc1⁺ or sgRNA3, when compared to EGFP. Data are shown as the mean ± SD. ns no significance. Statistical analysis was performed by multiple unpaired t-test