TABLE 4.
Patients with specific APOE isoforms and effect of treatment on lipid levels.
| Parameter | Group | Baseline | Follow-up | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean ± SD | p | N | Mean ± SD | p | N | Diference (%) | p | ||
| LDL-C (mmol/L) | E3E4 | 219 | 6.40 ± 1.80 | p = 0.753 | 212 | 3.09 ± 1.36 | p = 0.034 | 202 | −50.9 | p = 0.615 |
| E2E3 | 63 | 6.58 ± 2.22 | 59 | 3.27 ± 1.45 | 58 | −50.3 | ||||
| E3E3 | 651 | 6.49 ± 1.92 | 603 | 3.32 ± 1.65 | 588 | −49.0 | ||||
| E2E4 | 9 | 6.03 ± 2.36 | 11 | 2.45 ± 0.77 | 9 | −57.8 | ||||
| E4E4 | 22 | 5.94 ± 1.97 | 21 | 3.02 ± 1.26 | 21 | −49.0 | ||||
| E2E2 | 4 | 6.51 ± 1.30 | 6 | 1.77 ± 0.50 | 4 | −75.3 | ||||
| TC (mmol/L) | E3E4 | 230 | 8.90 ± 1.86 | p = 0.644 | 217 | 5.29 ± 1.46 | p = 0.126 | 217 | −40.5 | p = 0.202 |
| E2E3 | 65 | 8.93 ± 2.22 | 61 | 5.42 ± 1.62 | 61 | −39.6 | ||||
| E3E3 | 668 | 8.94 ± 1.97 | 619 | 5.48 ± 1.78 | 619 | −38.9 | ||||
| E2E4 | 11 | 8.29 ± 2.07 | 11 | 4.65 ± 0.84 | 11 | −43.9 | ||||
| E4E4 | 22 | 8.53 ± 1.98 | 21 | 5.38 ± 1.47 | 21 | −36.8 | ||||
| E2E2 | 6 | 9.82 ± 1.98 | 6 | 4.02 ± 0.60 | 6 | −59.0 | ||||
| APOB (g/L) | E3E4 | 116 | 1.79 ± 0.53 | p = 0.129 | 84 | 1.09 ± 0.46 | p = 0.361 | 47 | −37.7 | p = 0.933 |
| E2E3 | 35 | 1.67 ± 0.62 | 24 | 1.13 ± 0.40 | 14 | −32.3 | ||||
| E3E3 | 348 | 1.80 ± 0.54 | 182 | 1.08 ± 0.54 | 97 | −39.8 | ||||
| E2E4 | 6 | 1.76 ± 0.68 | 3 | 0.81 ± 0.10 | 2 | −45.5 | ||||
| E4E4 | 11 | 1.60 ± 0.34 | 7 | 0.78 ± 0.28 | 3 | −57.3 | ||||
| E2E2 | 5 | 1.22 ± 0.24 | 2 | 0.60 ± 0.11 | 1 | −53.5 | ||||
| TG (mmol/L) | E3E4 | 228 | 1.86 ± 1.28 | p < 0.001 | 217 | 1.44 ± 0.77 | p = 0.485 | 215 | −24.1 | p < 0.001 |
| E2E3 | 65 | 1.77 ± 1.10 | 61 | 1.34 ± 0.54 | 61 | −24.4 | ||||
| E3E3 | 662 | 1.73 ± 1.08 | 619 | 1.34 ± 0.83 | 613 | −23.6 | ||||
| E2E4 | 11 | 2.30 ± 1.68 | 11 | 1.39 ± 0.76 | 11 | −39.4 | ||||
| E4E4 | 22 | 1.76 ± 0.84 | 21 | 1.38 ± 0.72 | 21 | −22.4 | ||||
| E2E2 | 6 | 4.20 ± 2.50 | 6 | 1.84 ± 0.53 | 6 | −56.2 | ||||
| HDL-C (mmol/L) | E3E4 | 225 | 1.71 ± 0.47 | p = 0.141 | 214 | 1.58 ± 0.45 | p = 0.391 | 209 | −8.3 | p = 0.443 |
| E2E3 | 65 | 1.59 ± 0.51 | 60 | 1.53 ± 0.50 | 60 | −5.1 | ||||
| E3E3 | 662 | 1.67 ± 0.45 | 616 | 1.56 ± 0.47 | 610 | −7.1 | ||||
| E2E4 | 11 | 1.52 ± 0.53 | 11 | 1.57 ± 0.45 | 11 | 3.3 | ||||
| E4E4 | 22 | 1.85 ± 0.49 | 21 | 1.78 ± 0.55 | 21 | −4.5 | ||||
| E2E2 | 6 | 1.73 ± 0.41 | 6 | 1.43 ± 0.26 | 6 | −17.6 | ||||
| Lp(a) (g/L) | E3E4 | 199 | 0.52 ± 0.66 | p = 0.219 | 61 | 0.66 ± 0.73 | p = 0.361 | 60 | −3.8 | p = 0.692 |
| E2E3 | 51 | 0.32 ± 0.45 | 12 | 0.20 ± 0.18 | 12 | 10.0 | ||||
| E3E3 | 569 | 0.44 ± 0.56 | 173 | 0.53 ± 0.63 | 173 | 13.2 | ||||
| E2E4 | 9 | 0.42 ± 0.46 | 4 | 0.59 ± 0.95 | 4 | 51.3 | ||||
| E4E4 | 19 | 0.48 ± 0.62 | 5 | 0.94 ± 0.89 | 5 | 3.5 | ||||
| E2E2 | 6 | 0.16 ± 0.10 | 1 | 0.19 ± 0.00 | 1 | −36.7 | ||||
N, number of patients; SD, standard deviation; p, p-value.