Table 2.
Baseline characteristics of included patients in randomized trials.
| Trial/first author year | Group | Age, years | Male, % | Hypertension, % | Diabetes, % | Three-vessel diseases, % | Radial approach, % | DES, % | GpIIb/IIIa inhibitors, % |
|---|---|---|---|---|---|---|---|---|---|
| HELP AMI
20
2004 |
CO-PCI | 65.3 ± 7.4 | 84.6 | 58.8 | 41.2 | 47.1 | NA | NA | 82.4 |
| Immediate MV-PCI | 63.5 ± 12.4 | 88.2 | 36.5 | 11.5 | 30.8 | NA | NA | 75.0 | |
| Staged MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Politi et al. 21 | CO-PCI | 66.5 ± 13.2 | 76.2 | 59.5 | 23.8 | 25.0 | NA | 11.9 | NA |
| Immediate MV-PCI | 64.5 ± 11.7 | 76.9 | 49.2 | 13.8 | 29.2 | NA | 7.7 | NA | |
| Staged MV-PCI | 64.1 ± 11.1 | 80.0 | 64.6 | 18.5 | 44.6 | NA | 9.2 | NA | |
| Maamoun et al. 26 | CO-PCI | NA | NA | NA | NA | NA | NA | NA | NA |
| Immediate MV-PCI | 54.52 ± 10.3 | 95.2 | 38.1 | 40.5 | 26.2 | NA | 35.7 | NA | |
| Staged MV-PCI | 52.33 ± 7.1 | 88.9 | 33.3 | 55.6 | 22.2 | NA | 31.7 | NA | |
| Ghani et al. 23 | CO-PCI | 61 ± 11 | 80.5 | 42.5 | 5.0 | 19.5 | NA | 17.1 | 46.3 |
| Immediate MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Staged MV-PCI | 62 ± 10 | 80.0 | 26.3 | 6.3 | 25.0 | NA | 22.5 | 45.0 | |
| PRAMI
5
2013 |
CO-PCI | 62 | 81 | 40 | 21 | 33 | NA | 58 | 76 |
| Immediate MV-PCI | 62 | 76 | 40 | 15 | 39 | NA | 63 | 76 | |
| Staged MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Roman et al. 27 | CO-PCI | NA | NA | NA | NA | NA | NA | NA | NA |
| Immediate MV-PCI | 58.6 ± 11 | 69.6 | 95.6 | 26.1 | 43.5 | 43.5 | NA | NA | |
| Staged MV-PCI | 58.9 ± 10.4 | 58.1 | 86 | 20.9 | 46.5 | 53.5 | NA | NA | |
| DANAMI-3-PRIMULTI
7
2015 |
CO-PCI | 63 | 81 | 47 | 13 | 32 | NA | 93 | 23 |
| Immediate MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Staged MV-PCI | 64 | 80 | 41 | 9 | 31 | NA | 95 | 20 | |
| CvLPRIT
6
2015 a |
CO-PCI | 65.3 ± 11.9 | 76.7 | 36.4 | 14.3 | 24.7 | 72.9 | 90.7 | 31.7 |
| Immediate MV-PCI | 64.6 ± 11.2 | 85.3 | 36.6 | 12.9 | 20.7 | 76.7 | 95.9 | 31.7 | |
| Staged MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Zhang et al. 24 | CO-PCI | 61.88 ± 11.71 | 67.1 | 61.0 | 35.2 | NA | NA | 100 | 38.0 |
| Immediate MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Staged MV-PCI | 62.25 ± 9.96 | 60.9 | 64.2 | 36.7 | NA | NA | 100 | 35.3 | |
| PRAGUE 13
25
2015 |
CO-PCI | NA | NA | NA | NA | NA | NA | NA | NA |
| Immediate MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Staged MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Hamza et al.22,a | CO-PCI | 52.2 ± 10.6 | 86 | 36 | 100 | 34 | 46 | NA | 34 |
| Immediate MV-PCI | 56.4 ± 11.5 | 82 | 26 | 100 | 28 | 42 | NA | 38 | |
| Staged MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Compare-Acute
8
2017 a |
CO-PCI | 61 ± 10 | 76.3 | 47.8 | 15.9 | 32.9 | NA | NA | NA |
| Immediate MV-PCI | 62 ± 10 | 79 | 46.1 | 14.6 | 30.8 | NA | NA | NA | |
| Staged MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| COMPLETE
9
2019 |
CO-PCI | 62.4 ± 10.7 | 79.1 | 50.7 | 19.9 | 22.9 | 80.7 | NA | NA |
| Immediate MV-PCI | NA | NA | NA | NA | NA | NA | NA | NA | |
| Staged MV-PCI | 61.6 ± 10.7 | 80.5 | 48.7 | 19.1 | 23.9 | 80.8 | NA | NA |
AMI, acute myocardial infarction; Compare-Acute, Comparison Between FFR Guided Revascularization Versus Conventional Strategy in Acute STEMI Patients With Multivessel Coronary Artery Disease; COMPLETE, Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI; CO-PCI, culprit-only percutaneous coronary intervention; CvLPRIT, Complete Versus Lesion-Only Primary PCI Trial; DANAMI-3-PRIMULTI, Third Danish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: Primary PCI in Multivessel Disease; DES, drug-eluting stents; HELP AMI, HEpacoat for cuLPrit or multivessel stenting for Acute Myocardial Infarction; MV-PCI, multivessel percutaneous coronary intervention; PRAMI, Preventive Angioplasty in Myocardial Infarction.
MV-PCI was performed either immediately or staged and results were mixed, and the results were shown in the group that included more patients.