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. 2022 Feb 28;4:814975. doi: 10.3389/fspor.2022.814975

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Copyright © 2022 Gasser, Franchi, Ruoss, Frei, Popp, Niederseer, Catuogno, Frey and Flück.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Muscle deoxygenation during exercise is associated with the interaction between the aerobic fitness state and the angiotensin-converting enzyme-insertion/deletion (ACE-I/D) genotype. Box Whisker plots for the Δ_deoxgenation (A) and the slope of deoxygenation (B) in VAS and GAS combined in the function of the aerobic fitness status and the ACE-I/D genotype. Lines connect conditions demonstrating significant differences at *p < 0.05 and **p < 0.01. ANOVA for the factor “aerobic fitness” with post-hoc test of least significant difference.